Zi-Wei Li1, Hua Huang1, Yao Qin2, Kun-Quan Xiao2, Wei-Zao Luo3, Yong Yang3, Dan-Dan Gu4. 1. Department of Pharmaceutics, Chongqing Medical University, Chongqing 400016, China. 2. Taiji Group, Chongqing 401147, China. 3. Chongqing Institute of Traditional Chinese Medicine, Key Laboratory of Natural Resources of Chinese Medicinal Materials of Chongqing, Chongqing 400065, China. 4. Department of Medicinal Chemistry, Chengdu Chinese Medicine University, Chengdu 610041, China.
Abstract
OBJECTIVE: To prepare and optimize the conditions of Sodium Aescinat micro-emulsion for injection. METHODS: Sodium Aescinat O/W micro-emulsion (soybean phospholipids + HS15/glycerin/medium chain triglycerides/water) was formulated guided by the pseudo-titration ternary phase diagram. RESULTS: Stable Sodium Aescinat micro-emulsion was obtained with medium chain triglycerides as oil, soybean phospholipids + HS15 (1:2) as emulsifier, glycerin as co-emulsifier, and a ratio of emulsifier and co-emulsifier (Km) between 2.00-3.75. CONCLUSION: Stable Sodium Aescinat micro-emulsion can be prepared with conditions described in this study.
OBJECTIVE: To prepare and optimize the conditions of Sodium Aescinat micro-emulsion for injection. METHODS:Sodium Aescinat O/W micro-emulsion (soybeanphospholipids + HS15/glycerin/medium chain triglycerides/water) was formulated guided by the pseudo-titration ternary phase diagram. RESULTS: Stable Sodium Aescinat micro-emulsion was obtained with medium chain triglycerides as oil, soybeanphospholipids + HS15 (1:2) as emulsifier, glycerin as co-emulsifier, and a ratio of emulsifier and co-emulsifier (Km) between 2.00-3.75. CONCLUSION: Stable Sodium Aescinat micro-emulsion can be prepared with conditions described in this study.