Literature DB >> 24527061

Is modulating translation a therapeutic option for Huntington's disease?

Flaviano Giorgini1.   

Abstract

Entities:  

Year:  2011        PMID： 24527061      PMCID： PMC3920366          DOI： 10.2217/nmt.11.12

Source DB:  PubMed          Journal:  Neurodegener Dis Manag        ISSN： 1758-2024


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  23 in total

1.  DNA microarray analysis of striatal gene expression in symptomatic transgenic Huntington's mice (R6/2) reveals neuroinflammation and insulin associations.

Authors:  Susan F Crocker; Willard J Costain; Harold A Robertson
Journal:  Brain Res       Date:  2006-04-19       Impact factor: 3.252

2.  A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease.

Authors:  Flaviano Giorgini; Paolo Guidetti; QuangVu Nguyen; Simone C Bennett; Paul J Muchowski
Journal:  Nat Genet       Date:  2005-04-03       Impact factor: 38.330

3.  LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction.

Authors:  Seongsoo Lee; Hsin-Ping Liu; Wei-Yong Lin; Huifu Guo; Bingwei Lu
Journal:  J Neurosci       Date:  2010-12-15       Impact factor: 6.167

Review 4.  Huntington's disease: the challenge for cell biologists.

Authors:  A J Tobin; E R Signer
Journal:  Trends Cell Biol       Date:  2000-12       Impact factor: 20.808

5.  Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry.

Authors:  Heike Runne; Etienne Régulier; Alexandre Kuhn; Diana Zala; Ozgun Gokce; Valérie Perrin; Beate Sick; Patrick Aebischer; Nicole Déglon; Ruth Luthi-Carter
Journal:  J Neurosci       Date:  2008-09-24       Impact factor: 6.167

6.  Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila.

Authors:  Yuzuru Imai; Stephan Gehrke; Hua-Qin Wang; Ryosuke Takahashi; Kazuko Hasegawa; Etsuro Oota; Bingwei Lu
Journal:  EMBO J       Date:  2008-08-14       Impact factor: 11.598

7.  Translating translation: regulated protein translation as a biomedical intervention.

Authors:  Luke S Tain; Alexander J Whitworth
Journal:  Fly (Austin)       Date:  2009-10-01       Impact factor: 2.160

8.  Functional gene expression profiling in yeast implicates translational dysfunction in mutant huntingtin toxicity.

Authors:  Eran Tauber; Leonor Miller-Fleming; Robert P Mason; Wanda Kwan; Jannine Clapp; Nicola J Butler; Tiago F Outeiro; Paul J Muchowski; Flaviano Giorgini
Journal:  J Biol Chem       Date:  2010-11-02       Impact factor: 5.157

9.  Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss.

Authors:  Luke S Tain; Heather Mortiboys; Ran N Tao; Elena Ziviani; Oliver Bandmann; Alexander J Whitworth
Journal:  Nat Neurosci       Date:  2009-08-16       Impact factor: 24.884

10.  The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation.

Authors:  Azad Kumar; Elisa Greggio; Alexandra Beilina; Alice Kaganovich; Diane Chan; Jean-Marc Taymans; Benjamin Wolozin; Mark R Cookson
Journal:  PLoS One       Date:  2010-01-15       Impact factor: 3.240
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  1 in total

1.  Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein.

Authors:  Lois S Weisman; Juan Botas; Ismael Al-Ramahi; Sai Srinivas Panapakkam Giridharan; Yu-Chi Chen; Samarjit Patnaik; Nathaniel Safren; Junya Hasegawa; Maria de Haro; Amanda K Wagner Gee; Steven A Titus; Hyunkyung Jeong; Jonathan Clarke; Dimitri Krainc; Wei Zheng; Robin F Irvine; Sami Barmada; Marc Ferrer; Noel Southall; Juan Jose Marugan
Journal:  Elife       Date:  2017-12-26       Impact factor: 8.140
  1 in total

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