Literature DB >> 24526878

mTOR Strikes Again: mTORC1 Activation Causes Epilepsy Independent of Overt Pathological Changes.

Michael Wong.   

Abstract

Entities:  

Year:  2014        PMID： 24526878      PMCID： PMC3913314          DOI： 10.5698/1535-7597-14.1.41

Source DB:  PubMed          Journal:  Epilepsy Curr        ISSN： 1535-7511            Impact factor:   7.500


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  13 in total

1.  Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation.

Authors:  Erwin A van Vliet; Grazia Forte; Linda Holtman; Jeroen C G den Burger; Arno Sinjewel; Helga E de Vries; Eleonora Aronica; Jan A Gorter
Journal:  Epilepsia       Date:  2012-05-21       Impact factor: 5.864

2.  Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy.

Authors:  Xiaoxing Huang; Hailong Zhang; Jun Yang; Jingfan Wu; John McMahon; Yufan Lin; Zhonglian Cao; Michael Gruenthal; Yunfei Huang
Journal:  Neurobiol Dis       Date:  2010-05-26       Impact factor: 5.996

3.  mTOR inhibition modulates epileptogenesis, seizures and depressive behavior in a genetic rat model of absence epilepsy.

Authors:  Emilio Russo; Rita Citraro; Giuseppe Donato; Caterina Camastra; Rodolfo Iuliano; Salvatore Cuzzocrea; Andrew Constanti; Giovambattista De Sarro
Journal:  Neuropharmacology       Date:  2012-10-22       Impact factor: 5.250

4.  The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy.

Authors:  Ling-Hui Zeng; Nicholas R Rensing; Michael Wong
Journal:  J Neurosci       Date:  2009-05-27       Impact factor: 6.167

5.  Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia.

Authors:  M Cecilia Ljungberg; C Nicole Sunnen; Joaquin N Lugo; Anne E Anderson; Gabriella D'Arcangelo
Journal:  Dis Model Mech       Date:  2009-05-26       Impact factor: 5.758

Review 6.  A critical review of mTOR inhibitors and epilepsy: from basic science to clinical trials.

Authors:  Michael Wong
Journal:  Expert Rev Neurother       Date:  2013-06       Impact factor: 4.618

7.  PI3K-Akt signaling activates mTOR-mediated epileptogenesis in organotypic hippocampal culture model of post-traumatic epilepsy.

Authors:  Yevgeny Berdichevsky; Alexandra M Dryer; Yero Saponjian; Mark M Mahoney; Corrin A Pimentel; Corrina A Lucini; Marija Usenovic; Kevin J Staley
Journal:  J Neurosci       Date:  2013-05-22       Impact factor: 6.167

8.  The mTOR inhibitor rapamycin has limited acute anticonvulsant effects in mice.

Authors:  Adam L Hartman; Polan Santos; Alison Dolce; J Marie Hardwick
Journal:  PLoS One       Date:  2012-09-12       Impact factor: 3.240

9.  Rapamycin attenuates the development of posttraumatic epilepsy in a mouse model of traumatic brain injury.

Authors:  Dongjun Guo; Linghui Zeng; David L Brody; Michael Wong
Journal:  PLoS One       Date:  2013-05-14       Impact factor: 3.240

10.  The interaction between early life epilepsy and autistic-like behavioral consequences: a role for the mammalian target of rapamycin (mTOR) pathway.

Authors:  Delia M Talos; Hongyu Sun; Xiangping Zhou; Erin C Fitzgerald; Michele C Jackson; Peter M Klein; Victor J Lan; Annelise Joseph; Frances E Jensen
Journal:  PLoS One       Date:  2012-05-02       Impact factor: 3.240
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  3 in total

1.  Analysis of Proteins That Rapidly Change Upon Mechanistic/Mammalian Target of Rapamycin Complex 1 (mTORC1) Repression Identifies Parkinson Protein 7 (PARK7) as a Novel Protein Aberrantly Expressed in Tuberous Sclerosis Complex (TSC).

Authors:  Farr Niere; Sanjeev Namjoshi; Ehwang Song; Geoffrey A Dilly; Grant Schoenhard; Boris V Zemelman; Yehia Mechref; Kimberly F Raab-Graham
Journal:  Mol Cell Proteomics       Date:  2015-09-29       Impact factor: 5.911

2.  mTORC1 Is a Local, Postsynaptic Voltage Sensor Regulated by Positive and Negative Feedback Pathways.

Authors:  Farr Niere; Kimberly F Raab-Graham
Journal:  Front Cell Neurosci       Date:  2017-05-30       Impact factor: 5.505

Review 3.  Screening the Molecular Framework Underlying Local Dendritic mRNA Translation.

Authors:  Sanjeev V Namjoshi; Kimberly F Raab-Graham
Journal:  Front Mol Neurosci       Date:  2017-02-24       Impact factor: 5.639
  3 in total

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