Literature DB >> 24526196

Severe systemic Bacillus anthracis infection in an intravenous drug user.

Jessica Veitch1, Anoushka Kansara, Daniel Bailey, Ildiko Kustos.   

Abstract

There has recently been an outbreak of injectional anthrax infection secondary to contaminated heroin use in the UK and Europe. We present a case of a 37-year-old man presenting with pain and swelling in the groin following injection of heroin into the area. He was initially treated for severe cellulitis, however, he failed to respond to appropriate antimicrobial therapy. He went onto develop a widespread rash; it was then that a diagnosis of injectional anthrax infection was considered. Appropriate investigations were initiated including serum sample and tissue biopsy, and the diagnosis was confirmed. Management included extensive surgical debridement and a prolonged course of combination antibiotic therapy. The authors summarise the important steps in diagnosis and the management options in patients presenting with this life-threatening infection.

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Year:  2014        PMID: 24526196      PMCID: PMC3926448          DOI: 10.1136/bcr-2013-201921

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  4 in total

1.  Injectional anthrax in a heroin skin-popper.

Authors:  S H Ringertz; E A Høiby; M Jensenius; J Maehlen; D A Caugant; A Myklebust; K Fossum
Journal:  Lancet       Date:  2000-11-04       Impact factor: 79.321

Review 2.  An overview of anthrax infection including the recently identified form of disease in injection drug users.

Authors:  Caitlin W Hicks; Daniel A Sweeney; Xizhong Cui; Yan Li; Peter Q Eichacker
Journal:  Intensive Care Med       Date:  2012-04-24       Impact factor: 17.440

3.  Real-time PCR system targeting a chromosomal marker specific for Bacillus anthracis.

Authors:  Markus H Antwerpen; Pia Zimmermann; Kevin Bewley; Dimitrios Frangoulidis; Hermann Meyer
Journal:  Mol Cell Probes       Date:  2008-06-17       Impact factor: 2.365

4.  Injection anthrax--a new outbreak in heroin users.

Authors:  Roland Grunow; Luzie Verbeek; Daniela Jacob; Thomas Holzmann; Gabriele Birkenfeld; Daniel Wiens; Leonie von Eichel-Streiber; Gregor Grass; Udo Reischl
Journal:  Dtsch Arztebl Int       Date:  2012-12-07       Impact factor: 5.594

  4 in total
  2 in total

Review 1.  Antimicrobial Treatment for Systemic Anthrax: Analysis of Cases from 1945 to 2014 Identified Through a Systematic Literature Review.

Authors:  Satish K Pillai; Eileen Huang; Julie T Guarnizo; Jamechia D Hoyle; Stefan Katharios-Lanwermeyer; Theresa K Turski; William A Bower; Katherine A Hendricks; Dana Meaney-Delman
Journal:  Health Secur       Date:  2015-12-01

2.  Whole genome protein microarrays for serum profiling of immunodominant antigens of Bacillus anthracis.

Authors:  Karen E Kempsell; Stephen P Kidd; Kuiama Lewandowski; Michael J Elmore; Sue Charlton; Annemarie Yeates; Hannah Cuthbertson; Bassam Hallis; Daniel M Altmann; Mitch Rogers; Pierre Wattiau; Rebecca J Ingram; Tim Brooks; Richard Vipond
Journal:  Front Microbiol       Date:  2015-08-13       Impact factor: 5.640

  2 in total

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