Antigenic features and structural correlates of basement membranes. Relationship to epidermolysis bullosa.

Numerous antigenic epitopes are present within the dermoepidermal junction of human skin. Using monoclonal antibodies, the distribution of these epitopes in ontogeny, wound healing, and epidermolysis bullosa are being defined. These studies provide insight into the pathogenic mechanisms involved and offer opportunities for prenatal and postnatal diagnosis.