F Granado-Lorencio1, L Muñoz Garcia-Heras2, I Blanco-Navarro3, B Pérez-Sacristán4. 1. Unidad de Vitaminas, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain; Servicio de Bioquímica Clínica, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain. Electronic address: fgranado.hpth@salud.madrid.org. 2. Servicio de Bioquímica Clínica, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain. 3. Unidad de Vitaminas, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain; Servicio de Bioquímica Clínica, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain. 4. Unidad de Vitaminas, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain.
Abstract
OBJECTIVE: We aim to determine 3-epi-25-OH-D₃ in 155 leftover infant samples (<12 months) and its relationship with demographic, anthropometric and biochemical markers. METHODS: Samples were randomly collected and assessed for 3-epi-25-OH-D3 by HPLC. Biochemical data were recorded, if available, including C-reactive protein, calcium, liver and renal markers. Season of birth, gestational age (pre-term vs full-term), weight and height were recorded for infants <1 month. RESULTS: 3-Epi-25-OH-D₃ was quantified in 97% of the samples. Serum levels of the epimer increased at the end of the pregnancy and decreased over the first year of life. 3-Epi-25-OH-D₃ was negatively associated with bilirubin and C-reactive protein but unrelated to gestational age, season, age after delivery, height and weight, and calcemia or renal function. CONCLUSIONS: Based on the present data, both liver function and acute phase reactants should be considered when measuring 3-epi-25-OH-D₃ and assessing vitamin D status in infants.
OBJECTIVE: We aim to determine 3-epi-25-OH-D₃ in 155 leftover infant samples (<12 months) and its relationship with demographic, anthropometric and biochemical markers. METHODS: Samples were randomly collected and assessed for 3-epi-25-OH-D3 by HPLC. Biochemical data were recorded, if available, including C-reactive protein, calcium, liver and renal markers. Season of birth, gestational age (pre-term vs full-term), weight and height were recorded for infants <1 month. RESULTS: 3-Epi-25-OH-D₃ was quantified in 97% of the samples. Serum levels of the epimer increased at the end of the pregnancy and decreased over the first year of life. 3-Epi-25-OH-D₃ was negatively associated with bilirubin and C-reactive protein but unrelated to gestational age, season, age after delivery, height and weight, and calcemia or renal function. CONCLUSIONS: Based on the present data, both liver function and acute phase reactants should be considered when measuring 3-epi-25-OH-D₃ and assessing vitamin D status in infants.
Authors: Nina Ooms; Henny van Daal; Antonius M Beijers; G Peter J M Gerrits; Ben A Semmekrot; Johannes M W van den Ouweland Journal: Pediatr Res Date: 2015-12-28 Impact factor: 3.756
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