| Literature DB >> 24525233 |
Shi Jiao1, Huizhen Wang1, Zhubing Shi1, Aimei Dong2, Wenjing Zhang1, Xiaomin Song1, Feng He1, Yicui Wang1, Zhenzhen Zhang1, Wenjia Wang1, Xin Wang1, Tong Guo1, Peixue Li1, Yun Zhao1, Hongbin Ji3, Lei Zhang4, Zhaocai Zhou5.
Abstract
The Hippo pathway has been implicated in suppressing tissue overgrowth and tumor formation by restricting the oncogenic activity of YAP. However, transcriptional regulators that inhibit YAP activity have not been well studied. Here, we uncover clinical importance for VGLL4 in gastric cancer suppression and find that VGLL4 directly competes with YAP for binding TEADs. Importantly, VGLL4's tandem Tondu domains are not only essential but also sufficient for its inhibitory activity toward YAP. A peptide mimicking this function of VGLL4 potently suppressed tumor growth in vitro and in vivo. These findings suggest that disruption of YAP-TEADs interaction by a VGLL4-mimicking peptide may be a promising therapeutic strategy against YAP-driven human cancers.Entities:
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Year: 2014 PMID： 24525233 DOI： 10.1016/j.ccr.2014.01.010
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743