Literature DB >> 24525228

"Atypical" regulation of Hedgehog-dependent cancers.

Scott X Atwood1, Anthony E Oro2.   

Abstract

Growing evidence indicates targeting PKCι may be effective in treating Hedgehog-dependent cancers. In this issue of Cancer Cell, Justilien and colleagues present the surprising finding that PKCι promotes Hedgehog ligand production and lung squamous cell carcinoma growth through SOX2, rather than the canonical transcription factor GLI.
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID： 24525228      PMCID： PMC4024826          DOI： 10.1016/j.ccr.2014.01.027

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  10 in total

1.  PKCι maintains a tumor-initiating cell phenotype that is required for ovarian tumorigenesis.

Authors:  Yin Wang; Kristen S Hill; Alan P Fields
Journal:  Mol Cancer Res       Date:  2013-10-30       Impact factor: 5.852

Review 2.  The mechanisms of Hedgehog signalling and its roles in development and disease.

Authors:  James Briscoe; Pascal P Thérond
Journal:  Nat Rev Mol Cell Biol       Date:  2013-05-30       Impact factor: 94.444

3.  Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer.

Authors:  Roderick P Regala; Capella Weems; Lee Jamieson; Andras Khoor; Eric S Edell; Christine M Lohse; Alan P Fields
Journal:  Cancer Res       Date:  2005-10-01       Impact factor: 12.701

Review 4.  Polarity in mammalian epithelial morphogenesis.

Authors:  Julie Roignot; Xiao Peng; Keith Mostov
Journal:  Cold Spring Harb Perspect Biol       Date:  2013-02-01       Impact factor: 10.005

5.  The hedgehog processing pathway is required for NSCLC growth and survival.

Authors:  J Rodriguez-Blanco; N S Schilling; R Tokhunts; C Giambelli; J Long; D Liang Fei; S Singh; K E Black; Z Wang; F Galimberti; P A Bejarano; S Elliot; M K Glassberg; D M Nguyen; W W Lockwood; W L Lam; E Dmitrovsky; A J Capobianco; D J Robbins
Journal:  Oncogene       Date:  2012-06-25       Impact factor: 9.867

6.  Frequent requirement of hedgehog signaling in non-small cell lung carcinoma.

Authors:  Z Yuan; J A Goetz; S Singh; S K Ogden; W J Petty; C C Black; V A Memoli; E Dmitrovsky; D J Robbins
Journal:  Oncogene       Date:  2006-08-14       Impact factor: 9.867

7.  The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma.

Authors:  Verline Justilien; Michael P Walsh; Syed A Ali; E Aubrey Thompson; Nicole R Murray; Alan P Fields
Journal:  Cancer Cell       Date:  2014-02-10       Impact factor: 31.743

8.  Hedgehog pathway inhibition and the race against tumor evolution.

Authors:  Scott X Atwood; Anne Lynn S Chang; Anthony E Oro
Journal:  J Cell Biol       Date:  2012-10-15       Impact factor: 10.539

9.  Gli1 mediates lung cancer cell proliferation and Sonic Hedgehog-dependent mesenchymal cell activation.

Authors:  Olga Bermudez; Elisabeth Hennen; Ina Koch; Michael Lindner; Oliver Eickelberg
Journal:  PLoS One       Date:  2013-05-07       Impact factor: 3.240

10.  GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas.

Authors:  Scott X Atwood; Mischa Li; Alex Lee; Jean Y Tang; Anthony E Oro
Journal:  Nature       Date:  2013-02-28       Impact factor: 49.962
  10 in total
  4 in total

1.  A novel therapeutic approach against B-cell non-Hodgkin's lymphoma through co-inhibition of Hedgehog signaling pathway and autophagy.

Authors:  Jiajun Fan; Xian Zeng; Yubin Li; Shaofei Wang; Ping Yang; Zhonglian Cao; Ziyu Wang; Ping Song; Xiaobin Mei; Dianwen Ju
Journal:  Tumour Biol       Date:  2015-12-15

2.  Zinc inhibits Hedgehog autoprocessing: linking zinc deficiency with Hedgehog activation.

Authors:  Jian Xie; Timothy Owen; Ke Xia; Ajay Vikram Singh; Emiley Tou; Lingyun Li; Brigitte Arduini; Hongmin Li; Leo Q Wan; Brian Callahan; Chunyu Wang
Journal:  J Biol Chem       Date:  2015-03-18       Impact factor: 5.157

3.  Different Response of Ptch Mutant and Ptch Wildtype Rhabdomyosarcoma Toward SMO and PI3K Inhibitors.

Authors:  Natalie Geyer; Rosalie Ridzewski; Julia Bauer; Maria Kuzyakova; Kai Dittmann; Christian Dullin; Albert Rosenberger; Hans-Ulrich Schildhaus; Anja Uhmann; Simone Fulda; Heidi Hahn
Journal:  Front Oncol       Date:  2018-09-25       Impact factor: 6.244

Review 4.  Cross-Talk between Wnt and Hh Signaling Pathways in the Pathology of Basal Cell Carcinoma.

Authors:  Felicite K Noubissi; Clement G Yedjou; Vladimir S Spiegelman; Paul B Tchounwou
Journal:  Int J Environ Res Public Health       Date:  2018-07-09       Impact factor: 3.390
  4 in total

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