Literature DB >> 2452522

Potentiation of DNA damage and cytotoxicity by calmodulin antagonists.

S A Rosenthal1, W N Hait.   

Abstract

Many physical and chemical agents used in anti-neoplastic therapy are known to act by effecting DNA damage. The possibility that calmodulin may be an important modulator of the response to DNA damage in eukaryotic cells has been explored in a number of studies which use calmodulin antagonists in combination with agents known to damage DNA. We review these studies and discuss the therapeutic potential of calmodulin antagonists in combination therapy.

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Year:  1988        PMID： 2452522      PMCID： PMC2590415     

Source DB:  PubMed          Journal:  Yale J Biol Med        ISSN： 0044-0086


  49 in total

1.  Identification of the Ca2+-dependent modulator protein as the fourth subunit of rabbit skeletal muscle phosphorylase kinase.

Authors:  P Cohen; A Burchell; J G Foulkes; P T Cohen; T C Vanaman; C Nairn
Journal:  FEBS Lett       Date:  1978-08-15       Impact factor: 4.124

2.  Ca2+-dependent protein phosphorylation system in membranes from various tissues, and its activation by "calcium-dependent regulator".

Authors:  H Schulman; P Greengard
Journal:  Proc Natl Acad Sci U S A       Date:  1978-11       Impact factor: 11.205

Review 3.  DNA repair in bacteria and mammalian cells.

Authors:  P C Hanawalt; P K Cooper; A K Ganesan; C A Smith
Journal:  Annu Rev Biochem       Date:  1979       Impact factor: 23.643

4.  Post-replication repair of DNA in ultraviolet-irradiated mammalian cells. No gaps in DNA synthesized late after ultraviolet irradiation.

Authors:  A R Lehmann
Journal:  Eur J Biochem       Date:  1972-12-18

5.  Inhibition of DNA repair by trifluoperazine.

Authors:  P A Charp; J D Regan
Journal:  Biochim Biophys Acta       Date:  1985-01-29

6.  Hyperthermic effects on DNA repair mechanisms.

Authors:  P M Corry; S Robinson; S Getz
Journal:  Radiology       Date:  1977-05       Impact factor: 11.105

7.  Single-agent chemotherapy of a solid murine tumor assayed by growth delay and cell survival.

Authors:  A C Begg; K K Fu; L J Kane; T L Phillips
Journal:  Cancer Res       Date:  1980-01       Impact factor: 12.701

Review 8.  Calmodulin plays a pivotal role in cellular regulation.

Authors:  W Y Cheung
Journal:  Science       Date:  1980-01-04       Impact factor: 47.728

Review 9.  Prospects for hyperthermia in human cancer therapy. Part I: hyperthermic effects in man and spontaneous animal tumors.

Authors:  R C Miller; W G Connor; R S Heusinkveld; M L Boone
Journal:  Radiology       Date:  1977-05       Impact factor: 11.105

Review 10.  Prospects for hyperthermia in human cancer therapy. Part II: implications of biological and physical data for applications of hyperthermia to man.

Authors:  W G Connor; E W Gerner; R C Miller; M L Boone
Journal:  Radiology       Date:  1977-05       Impact factor: 11.105
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