Edwin van Wijngaarden1, Donald Harrington2, Roni Kobrosly3, Sally W Thurston2, Todd O'Hara4, Emeir M McSorley5, Gary J Myers6, Gene E Watson7, Conrad F Shamlaye8, J J Strain5, Philip W Davidson9. 1. Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, NY; Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, NY. Electronic address: edwin_van_wijngaarden@urmc.rochester.edu. 2. Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, NY. 3. Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, NY. 4. Department of Veterinary Medicine, College of Natural Sciences and Mathematics, University of Alaska Fairbanks, AK. 5. Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland. 6. Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, NY; Department of Neurology, University of Rochester School of Medicine and Dentistry, NY; Department of Pediatrics, University of Rochester School of Medicine and Dentistry, NY. 7. Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, NY; Department of Neurology, University of Rochester School of Medicine and Dentistry, NY; Eastman Department of Dentistry, University of Rochester School of Medicine and Dentistry, NY. 8. Ministry of Health, Victoria, Mahé, Republic of Seychelles. 9. Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, NY; Department of Pediatrics, University of Rochester School of Medicine and Dentistry, NY.
Abstract
BACKGROUND: Epidemiologic studies have been inconclusive regarding the impact of coexposure to long chain polyunsaturated fatty acids (LCPUFA) and methylmercury (MeHg) from fish consumption during pregnancy on measures of fetal development. OBJECTIVES: We evaluated the association between birth weight and prenatal maternal LCPUFA status and MeHg exposure in the Republic of Seychelles. METHODS: We measured LCPUFA in maternal whole blood collected at 28 weeks of gestation and following delivery and MeHg in maternal hair obtained at delivery. There were 230 births with complete data on birth weight and covariates. Multiple linear regression models controlled for infant sex, gestational age, maternal age, smoking during pregnancy, intrapartum weight gain, prepregnancy body mass index, maternal socioeconomic status, parity, gestational diabetes, and alcohol use during pregnancy. RESULTS: The average birth weight was 3252 g (range 1654-4450) and the average gestational age was 39 weeks (range 34-41). Prenatal MeHg exposure and maternal LCPUFA status were not associated with birth weight. Infant sex and length of gestation were the only predictors, with male sex and increased gestational age consistently associated with greater birth weight. CONCLUSIONS: These findings do not support a relationship between prenatal exposure to LCPUFA and/or MeHg from fish consumption and birth weight.
BACKGROUND: Epidemiologic studies have been inconclusive regarding the impact of coexposure to long chain polyunsaturated fatty acids (LCPUFA) and methylmercury (MeHg) from fish consumption during pregnancy on measures of fetal development. OBJECTIVES: We evaluated the association between birth weight and prenatal maternal LCPUFA status and MeHg exposure in the Republic of Seychelles. METHODS: We measured LCPUFA in maternal whole blood collected at 28 weeks of gestation and following delivery and MeHg in maternal hair obtained at delivery. There were 230 births with complete data on birth weight and covariates. Multiple linear regression models controlled for infant sex, gestational age, maternal age, smoking during pregnancy, intrapartum weight gain, prepregnancy body mass index, maternal socioeconomic status, parity, gestational diabetes, and alcohol use during pregnancy. RESULTS: The average birth weight was 3252 g (range 1654-4450) and the average gestational age was 39 weeks (range 34-41). Prenatal MeHg exposure and maternal LCPUFA status were not associated with birth weight. Infant sex and length of gestation were the only predictors, with male sex and increased gestational age consistently associated with greater birth weight. CONCLUSIONS: These findings do not support a relationship between prenatal exposure to LCPUFA and/or MeHg from fish consumption and birth weight.
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