Literature DB >> 24524741

Rapid generation of privileged substructure-based compound libraries with structural diversity and drug-likeness.

Lei Zhang1, Mingyue Zheng, Fei Zhao, Yun Zhai, Hong Liu.   

Abstract

A library of privileged-substructure-based, heterocyclic compounds was constructed by a sequence of Ugi four-component reactions incorporating the indole motif and microwave-assisted cyclizations in branched pathways. Cheminformatic analysis confirmed that the library exhibited a high degree of structural diversity and good drug-likeness.

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Year:  2014        PMID： 24524741     DOI： 10.1021/co4001309

Source DB:  PubMed          Journal:  ACS Comb Sci        ISSN： 2156-8944            Impact factor:   3.784


  4 in total

Review 1.  Applications of Palladium-Catalyzed C-N Cross-Coupling Reactions.

Authors:  Paula Ruiz-Castillo; Stephen L Buchwald
Journal:  Chem Rev       Date:  2016-09-30       Impact factor: 60.622

2.  Rapid synthetic approaches to libraries of diversified 1,2-dihydrochromeno[2,3-c]pyrrole-3,9-diones and 3-(2-hydroxyphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones.

Authors:  Roman N Vydzhak; Svitlana Ya Panchishin; Maryna V Kachaeva; Stepan G Pilyo; Viktoriia S Moskvina; Olga V Shablykina; Andriy V Kozytskiy; Volodymyr S Brovarets
Journal:  Mol Divers       Date:  2021-06-04       Impact factor: 3.364

3.  Thiazine-2-thiones as Masked 1-Azadienes in Cascade Dimerization Reactions).

Authors:  Art Kruithof; Christophe M L Vande Velde; Eelco Ruijter; Romano V A Orru
Journal:  Molecules       Date:  2017-03-28       Impact factor: 4.411

Review 4.  Diversity-oriented synthetic strategies applied to cancer chemical biology and drug discovery.

Authors:  Ian Collins; Alan M Jones
Journal:  Molecules       Date:  2014-10-27       Impact factor: 4.411
  4 in total

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