Literature DB >> 24524683

Mass spectrometric proteomics reveals that nuclear protein positive cofactor PC4 selectively binds to cross-linked DNA by a trans-platinum anticancer complex.

Zhifeng Du1, Qun Luo, Liping Yang, Tao Bing, Xianchan Li, Wei Guo, Kui Wu, Yao Zhao, Shaoxiang Xiong, Dihua Shangguan, Fuyi Wang.   

Abstract

An MS-based proteomic strategy combined with chemically functionalized gold nanoparticles as affinity probes was developed and validated by successful identification and quantification of HMGB1, which is well characterized to interact selectively with 1,2-cross-linked DNA by cisplatin, from whole cell lysates. The subsequent application of this method to identify proteins responding to 1,3-cross-linked DNA by a trans-platinum anticancer complex, trans-PtTz (Tz = thiazole), revealed that the human nuclear protein positive cofactor PC4 selectively binds to the damaged DNA, implying that PC4 may play a role in cellular response to DNA damage by trans-PtTz.

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Year:  2014        PMID： 24524683     DOI： 10.1021/ja410678y

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  9 in total

1.  Identification of SLIRP as a G Quadruplex-Binding Protein.

Authors:  Preston Williams; Lin Li; Xiaoli Dong; Yinsheng Wang
Journal:  J Am Chem Soc       Date:  2017-09-05       Impact factor: 15.419

2.  Mitochondrial Transcription Factor A Binds to and Promotes Mutagenic Transcriptional Bypass of O4-Alkylthymidine Lesions.

Authors:  Xiaomei He; Pengcheng Wang; Yinsheng Wang
Journal:  Anal Chem       Date:  2020-12-08       Impact factor: 6.986

3.  HMGB1 bound to cisplatin-DNA adducts undergoes extensive acetylation and phosphorylation in vivo.

Authors:  Yafeng He; Yin Ding; Dan Wang; Wanjun Zhang; Weizhong Chen; Xichun Liu; Weijie Qin; Xiaohong Qian; Hao Chen; Zijian Guo
Journal:  Chem Sci       Date:  2014-12-15       Impact factor: 9.825

Review 4.  Elucidation of the Mechanism of Action for Metal Based Anticancer Drugs by Mass Spectrometry-Based Quantitative Proteomics.

Authors:  Shuailong Jia; Runjing Wang; Kui Wu; Hongliang Jiang; Zhifeng Du
Journal:  Molecules       Date:  2019-02-06       Impact factor: 4.411

5.  Transcriptional positive cofactor 4 promotes breast cancer proliferation and metastasis through c-Myc mediated Warburg effect.

Authors:  Peng Luo; Chi Zhang; Fengying Liao; Long Chen; Zhenyu Liu; Lei Long; Zhongyong Jiang; Yawei Wang; Ziwen Wang; Zujuan Liu; Hongming Miao; Chunmeng Shi
Journal:  Cell Commun Signal       Date:  2019-04-16       Impact factor: 5.712

6.  Positive Cofactor 4 as a Potential Radiation Biodosimeter for Early Assessment.

Authors:  Le Ma; Qiang Gong; Gaoyu Liu; Jieping Chen; Yu Wang; Peng Luo; Chunmeng Shi
Journal:  Dose Response       Date:  2022-02-23       Impact factor: 2.658

7.  G-quadruplex inducer/stabilizer pyridostatin targets SUB1 to promote cytotoxicity of a transplatinum complex.

Authors:  Yinzhu Hou; Tieliang Gan; Tiantian Fang; Yao Zhao; Qun Luo; Xingkai Liu; Luyu Qi; Yanyan Zhang; Feifei Jia; Juanjuan Han; Shumu Li; Shijun Wang; Fuyi Wang
Journal:  Nucleic Acids Res       Date:  2022-04-08       Impact factor: 16.971

8.  Baicalin Targets HSP70/90 to Regulate PKR/PI3K/AKT/eNOS Signaling Pathways.

Authors:  Yinzhu Hou; Zuqing Liang; Luyu Qi; Chao Tang; Xingkai Liu; Jilin Tang; Yao Zhao; Yanyan Zhang; Tiantian Fang; Qun Luo; Shijun Wang; Fuyi Wang
Journal:  Molecules       Date:  2022-02-21       Impact factor: 4.411

9.  PC4 serves as a negative regulator of skin wound healing in mice.

Authors:  Fengying Liao; Long Chen; Peng Luo; Zhongyong Jiang; Zelin Chen; Ziwen Wang; Chi Zhang; Yu Wang; Jintao He; Qing Wang; Yawei Wang; Lang Liu; Yu Huang; Huilan Wang; Qingzhi Jiang; Min Luo; Yibo Gan; Yunsheng Liu; Yang Wang; Jie Wu; Wentao Xie; Zhuo Cheng; Yali Dai; Jialun Li; Zujuan Liu; Fan Yang; Chunmeng Shi
Journal:  Burns Trauma       Date:  2020-05-05
  9 in total

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