Juan P de Torres1, Jose M Marin2, Cristina Martinez-Gonzalez3, Pilar de Lucas-Ramos4, Isabel Mir-Viladrich5, Borja Cosio6, German Peces-Barba7, Miryam Calle-Rubio8, Ingrid Solanes-García9, Ramón Agüero Balbin10, Alfredo de Diego-Damia11, Nuria Feu-Collado12, Inmaculada Alfageme Michavila13, Rosa Irigaray14, Eva Balcells15, Antònia Llunell Casanovas16, Juan Bautista Galdiz Iturri17, Margarita Marín Royo18, Juan J Soler-Cataluña19, Jose Luis Lopez-Campos20, Joan B Soriano21, Ciro Casanova22. 1. Pulmonary Department, Clínica Universidad de Navarra, Pamplona, Spain. Electronic address: jupa65@hotmail.com. 2. Pulmonary Department, Hospital Universitario Miguel Servet, Zaragoza, Spain; CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain. 3. Pulmonary Department, Hospital Central de Asturias, Oviedo, Spain. 4. Pulmonary Department I, Hospital Gregorio Marañon, Madrid, Spain. 5. Pulmonary Department, Hospital Son Llátzer, Palma de Mallorca, Madrid, Spain. 6. Pulmonary Department, Hospital Son Espases, Palma de Mallorca, Madrid, Spain; CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain. 7. Pulmonary Department, Fundación Jimenez Diaz, Madrid, Spain; CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain. 8. Pulmonary Department, Hospital Clinico San Carlos, Madrid, Spain. 9. Pulmonary Department, Hospital San Pablo y la Santa Cruz, Barcelona, Spain. 10. Pulmonary Department, Hospital Marques de Valdecilla, Santander, Spain. 11. Pulmonary Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain. 12. Pulmonary Department, Hospital Universitario Reina Sofía, Cordoba, Spain. 13. Pulmonary Department, Hospital Universitario de Valme, Sevilla, Spain. 14. Pulmonary Department, Hospital de Manacor, Mallorca, Spain. 15. Pulmonary Department, Hospital del Mar, Barcelona, Spain; CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain. 16. Pulmonary Department, Hospital de Terrassa, Terrassa, Spain. 17. Pulmonary Department, Hospital de Cruces, UPV/EHU, Bilbao, Spain; CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain. 18. Pulmonary Department, Hospital General de Castellón, Castellón, Spain. 19. Pulmonary Department, Hospital General de Requena, Valencia, Spain; CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain. 20. Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío, Sevilla, Spain; CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain. 21. Epidemiology and Clinical Research, CIMERA, Bunyola, Mallorca, Spain. 22. Pulmonary Department, Hospital Universitario Nuestra Señora de Candelaria, Tenerife, Spain.
Abstract
OBJECTIVE: The COPD Assessment Test (CAT) has been proposed for assessing health status in COPD, but little is known about its longitudinal changes. The objective of this study was to evaluate 1-year CAT variability in patients with stable COPD and to relate its variations to changes in other disease markers. METHODS: We evaluated the following variables in smokers with and without COPD at baseline and after 1 year: CAT score, age, sex, smoking status, pack-year history, BMI, modified Medical Research Council (mMRC) scale, 6-min walk distance (6MWD), lung function, BODE (BMI, obstruction, dyspnea, exercise capacity) index, hospital admissions, Hospital and Depression Scale, and the Charlson comorbidity index. In patients with COPD, we explored the association of CAT scores and 1-year changes in the studied parameters. RESULTS: A total of 824 smokers with COPD and 126 without COPD were evaluated at baseline and 441 smokers with COPD and 66 without COPD 1 year later. At 1 year, CAT scores for patients with COPD were similar (± 4 points) in 56%, higher in 27%, and lower in 17%. Of note, mMRC scale scores were similar (± 1 point) in 46% of patients, worse in 36%, and better in 18% at 1 year. One-year CAT changes were best predicted by changes in mMRC scale scores (β-coefficient, 0.47; P < .001). Similar results were found for CAT and mMRC scale score in smokers without COPD. CONCLUSIONS: One-year longitudinal data show variability in CAT scores among patients with stable COPD similar to mMRC scale score, which is the best predictor of 1-year CAT changes. Further longitudinal studies should confirm long-term CAT variability and its clinical applicability. TRIAL REGISTRY: ClinicalTrials.gov; No.: NCT01122758; URL: www.clinicaltrials.gov.
OBJECTIVE: The COPD Assessment Test (CAT) has been proposed for assessing health status in COPD, but little is known about its longitudinal changes. The objective of this study was to evaluate 1-year CAT variability in patients with stable COPD and to relate its variations to changes in other disease markers. METHODS: We evaluated the following variables in smokers with and without COPD at baseline and after 1 year: CAT score, age, sex, smoking status, pack-year history, BMI, modified Medical Research Council (mMRC) scale, 6-min walk distance (6MWD), lung function, BODE (BMI, obstruction, dyspnea, exercise capacity) index, hospital admissions, Hospital and Depression Scale, and the Charlson comorbidity index. In patients with COPD, we explored the association of CAT scores and 1-year changes in the studied parameters. RESULTS: A total of 824 smokers with COPD and 126 without COPD were evaluated at baseline and 441 smokers with COPD and 66 without COPD 1 year later. At 1 year, CAT scores for patients with COPD were similar (± 4 points) in 56%, higher in 27%, and lower in 17%. Of note, mMRC scale scores were similar (± 1 point) in 46% of patients, worse in 36%, and better in 18% at 1 year. One-year CAT changes were best predicted by changes in mMRC scale scores (β-coefficient, 0.47; P < .001). Similar results were found for CAT and mMRC scale score in smokers without COPD. CONCLUSIONS: One-year longitudinal data show variability in CAT scores among patients with stable COPD similar to mMRC scale score, which is the best predictor of 1-year CAT changes. Further longitudinal studies should confirm long-term CAT variability and its clinical applicability. TRIAL REGISTRY: ClinicalTrials.gov; No.: NCT01122758; URL: www.clinicaltrials.gov.
Authors: Jose Luis Lopez-Campos; Alberto Fernandez-Villar; Carmen Calero-Acuña; Cristina Represas-Represas; Cecilia Lopez-Ramírez; Virginia Leiro Fernández; Juan Jose Soler-Cataluña; Ricard Casamor Journal: Int J Chron Obstruct Pulmon Dis Date: 2015-05-27
Authors: Joanne M Sloots; Christopher A Barton; Julie Buckman; Katherine L Bassett; Job van der Palen; Peter A Frith; Tanja W Effing Journal: Chron Respir Dis Date: 2017-02-24 Impact factor: 2.444
Authors: Douglas W Mapel; Anand A Dalal; Phaedra T Johnson; Laura K Becker; Alyssa Goolsby Hunter Journal: Int J Chron Obstruct Pulmon Dis Date: 2015-07-30