Jeng-Feng Lin1, Semon Wu, Shun-Yi Hsu, Kuan-Hung Yeh, Hsin-Hua Chou, Shih-Tsung Cheng, Tien-Yu Wu, Wen-Tze Hsu, Chun-Chun Yang, Yu-Lin Ko. 1. Division of Cardiology (JFL, SYH, KHY, HHC, STC, TYW, WTH, YLK), Department of Internal Medicine, Buddhist Tzu-Chi Hospital, Taipei Branch, Taiwan; School of Medicine (JFL, SYH, KHY, YLK), Tzu Chi University, Hualien, Taiwan; Department of Laboratory Medicine (CCY), Buddhist Tzu Chi General Hospital, Taipei Branch, Taiwan; Department of Research (SW), Buddhist Tzu-Chi Hospital, Taipei Branch, Taiwan; and Department of Life Science (SW), Chinese Culture University, Taipei, Taiwan.
Abstract
BACKGROUND: Growth-differentiation factor (GDF)-15 is a strong predictor of cardiovascular events in patients with ST-elevation myocardial infarction (STEMI). However, the effects of GDF-15 on left ventricular (LV) remodeling have not been clearly elucidated. The aim of this study is to investigate whether GDF-15 will be of benefit in predicting LV remodeling, heart failure and death in patients with STEMI. METHODS: The authors enrolled 216 patients with STEMI who received measurement of GDF-15 level on day 2 of hospitalization. Echocardiographic studies were performed at baseline and were repeated 6 months later. Clinical events, including all-cause death and readmission for heart failure, were followed up for a maximum of 3 years. RESULTS: Patients with GDF-15 levels above the median had lower LV ejection fraction at baseline (43.9% versus 48.0%, P = 0.041) and at 6 months (51.5% versus 56.9%, P = 0.025). In univariable regression model, log-transformed GDF-15 level was not a predictor of increase in LV end-diastolic volume index at 6 months (P = 0.767). Kaplan-Meier survival curves showed that the combination of high GDF-15 and high N-terminal pro-B-type natriuretic peptide was a strong predictor of death and heart failure (P < 0.001). In multivariable Cox regression model, the independent predictors of death and heart failure were age, GDF-15 level and diabetes mellitus. CONCLUSIONS: High GDF-15 level is a strong predictor of death and heart failure in patients with STEMI. Although patients with higher GDF-15 levels tend to have lower LV ejection fraction, they have similar degree of the increase in LV end-diastolic volume index at 6 months.
BACKGROUND:Growth-differentiation factor (GDF)-15 is a strong predictor of cardiovascular events in patients with ST-elevation myocardial infarction (STEMI). However, the effects of GDF-15 on left ventricular (LV) remodeling have not been clearly elucidated. The aim of this study is to investigate whether GDF-15 will be of benefit in predicting LV remodeling, heart failure and death in patients with STEMI. METHODS: The authors enrolled 216 patients with STEMI who received measurement of GDF-15 level on day 2 of hospitalization. Echocardiographic studies were performed at baseline and were repeated 6 months later. Clinical events, including all-cause death and readmission for heart failure, were followed up for a maximum of 3 years. RESULTS:Patients with GDF-15 levels above the median had lower LV ejection fraction at baseline (43.9% versus 48.0%, P = 0.041) and at 6 months (51.5% versus 56.9%, P = 0.025). In univariable regression model, log-transformed GDF-15 level was not a predictor of increase in LV end-diastolic volume index at 6 months (P = 0.767). Kaplan-Meier survival curves showed that the combination of high GDF-15 and high N-terminal pro-B-type natriuretic peptide was a strong predictor of death and heart failure (P < 0.001). In multivariable Cox regression model, the independent predictors of death and heart failure were age, GDF-15 level and diabetes mellitus. CONCLUSIONS: High GDF-15 level is a strong predictor of death and heart failure in patients with STEMI. Although patients with higher GDF-15 levels tend to have lower LV ejection fraction, they have similar degree of the increase in LV end-diastolic volume index at 6 months.
Authors: Mustafa Umut Somuncu; Fatih Pasa Tatar; Belma Kalayci; Ahmet Avci; Naile Eris Gudul; Begum Uygur; Ali Riza Demir; Murat Can Journal: Acta Cardiol Sin Date: 2021-09 Impact factor: 2.672
Authors: Neeti Agarwal; Claudia E Ramirez Bustamante; Huaizhu Wu; Reina Armamento-Villareal; Jordan E Lake; Ashok Balasubramanyam; Sean M Hartig Journal: Physiol Rep Date: 2022-05
Authors: Judith J De Haan; Saskia Haitjema; Hester M den Ruijter; Gerard Pasterkamp; Gert J de Borst; Martin Teraa; Marianne C Verhaar; Hendrik Gremmels; Saskia C A de Jager Journal: J Am Heart Assoc Date: 2017-08-30 Impact factor: 5.501