Literature DB >> 24521669

Sensing the hybrid--a novel PAMP for TLR9.

Søren B Jensen1, Søren R Paludan.   

Abstract

The host immune response is initiated by pattern recognition receptors (PRR) when triggered by specific ligands known as pathogen-associated molecular patterns (PAMP). Toll-like receptor 9 is highly expressed in plasmacytoid dendritic cells and is well described as a PRR for CpG DNA which induce the production of cytokines and type I interferons. In this issue of The EMBO Journal, Rigby et al identify RNA-DNA hybrids as a novel PAMP specifically recognized by TLR9 in dendritic cells.

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Year:  2014        PMID： 24521669      PMCID： PMC3989645          DOI： 10.1002/embj.201487747

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  11 in total

1.  IFI16 is an innate immune sensor for intracellular DNA.

Authors:  Leonie Unterholzner; Sinead E Keating; Marcin Baran; Kristy A Horan; Søren B Jensen; Shruti Sharma; Cherilyn M Sirois; Tengchuan Jin; Eicke Latz; T Sam Xiao; Katherine A Fitzgerald; Søren R Paludan; Andrew G Bowie
Journal:  Nat Immunol       Date:  2010-10-03       Impact factor: 25.606

Review 2.  Toll-like receptor and RIG-I-like receptor signaling.

Authors:  Taro Kawai; Shizuo Akira
Journal:  Ann N Y Acad Sci       Date:  2008-11       Impact factor: 5.691

3.  Toll-like receptor polymorphism associations with HIV-1 outcomes among sub-Saharan Africans.

Authors:  Romel D Mackelprang; Abigail W Bigham; Connie Celum; Guy de Bruyn; Kristin Beima-Sofie; Grace John-Stewart; Allan Ronald; Nelly R Mugo; Kati J Buckingham; Michael J Bamshad; James I Mullins; M Juliana McElrath; Jairam R Lingappa
Journal:  J Infect Dis       Date:  2013-12-10       Impact factor: 5.226

Review 4.  The control of adaptive immune responses by the innate immune system.

Authors:  Dominik Schenten; Ruslan Medzhitov
Journal:  Adv Immunol       Date:  2011       Impact factor: 3.543

5.  Replication of the genome of a hepatitis B--like virus by reverse transcription of an RNA intermediate.

Authors:  J Summers; W S Mason
Journal:  Cell       Date:  1982-06       Impact factor: 41.582

6.  The DNA sugar backbone 2' deoxyribose determines toll-like receptor 9 activation.

Authors:  Tobias Haas; Jochen Metzger; Frank Schmitz; Antje Heit; Thomas Müller; Eicke Latz; Hermann Wagner
Journal:  Immunity       Date:  2008-03       Impact factor: 31.745

Review 7.  Immune sensing of DNA.

Authors:  Søren R Paludan; Andrew G Bowie
Journal:  Immunity       Date:  2013-05-23       Impact factor: 31.745

8.  Requirement for DNA CpG content in TLR9-dependent dendritic cell activation induced by DNA-containing immune complexes.

Authors:  Kei Yasuda; Christophe Richez; Melissa B Uccellini; Rocco J Richards; Ramon G Bonegio; Shizuo Akira; Marc Monestier; Ronald B Corley; Gregory A Viglianti; Ann Marshak-Rothstein; Ian R Rifkin
Journal:  J Immunol       Date:  2009-07-31       Impact factor: 5.422

Review 9.  Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity.

Authors:  Yanick J Crow; Jan Rehwinkel
Journal:  Hum Mol Genet       Date:  2009-10-15       Impact factor: 6.150

10.  RNA:DNA hybrids are a novel molecular pattern sensed by TLR9.

Authors:  Rachel E Rigby; Lauren M Webb; Karen J Mackenzie; Yue Li; Andrea Leitch; Martin A M Reijns; Rachel J Lundie; Ailsa Revuelta; Donald J Davidson; Sandra Diebold; Yorgo Modis; Andrew S MacDonald; Andrew P Jackson
Journal:  EMBO J       Date:  2014-02-10       Impact factor: 11.598
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  1 in total

1.  Multiple Immunosuppressive Effects of CpG-c41 on Intracellular TLR-Mediated Inflammation.

Authors:  Wancheng Liu; Xuejiao Yang; Ning Wang; Shijun Fan; Yuanfeng Zhu; Xinchuan Zheng; Yan Li
Journal:  Mediators Inflamm       Date:  2017-04-30       Impact factor: 4.711
  1 in total

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