Literature DB >> 2451930

Comparison of neurokinin A and substance P on cardiovascular and airway function in man.

T W Evans1, C M Dixon, B Clarke, T B Conradson, P J Barnes.   

Abstract

The airway and cardiovascular effects of intravenous neurokinin A (NKA) and substance P (SP) were compared in six normal subjects. Both SP and NKA increased skin temperature (SkT) and heart rate (HR), but SP was more potent than NKA by factors of 6 and 20 respectively. No change in systolic blood pressure (BP) occurred with either peptide, but diastolic BP fell significantly with SP infusion. SP caused bronchodilation and NKA bronchoconstriction. NKA and SP have differing physiological roles and may activate different receptor populations.

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Year:  1988        PMID： 2451930      PMCID： PMC1386485          DOI： 10.1111/j.1365-2125.1988.tb03302.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  5 in total

Review 1.  Neural control of human airways in health and disease.

Authors:  P J Barnes
Journal:  Am Rev Respir Dis       Date:  1986-12

2.  Effect of substance P and other tachykinins on arterial pressure in guinea-pigs.

Authors:  J C Hancock; D B Hoover
Journal:  J Auton Pharmacol       Date:  1985-03

3.  Comparison of cardiovascular and bronchoconstrictor effects of substance P, substance K and other tachykinins.

Authors:  X Hua; J M Lundberg; E Theodorsson-Norheim; E Brodin
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-12       Impact factor: 3.000

4.  Effect of substance P on cardiovascular and respiratory function in subjects.

Authors:  R W Fuller; D L Maxwell; C M Dixon; G P McGregor; V F Barnes; S R Bloom; P J Barnes
Journal:  J Appl Physiol (1985)       Date:  1987-04

5.  Multiple tachykinin binding sites in peripheral tissues and in brain.

Authors:  C M Lee; N J Campbell; B J Williams; L L Iversen
Journal:  Eur J Pharmacol       Date:  1986-11-04       Impact factor: 4.432
  5 in total
  18 in total

1.  Impairment of endothelium-dependent pulmonary vasodilation in patients with primary pulmonary hypertension.

Authors:  S J Brett; J Simon; R Gibbs; J R Pepper; T W Evans
Journal:  Thorax       Date:  1996-01       Impact factor: 9.139

2.  Colorectal and cardiovascular effects of [Lys5,MeLeu9,Nle10]-NKA(4-10) in anesthetized macaques.

Authors:  Nadia M J Rupniak; Mary Katofiasc; Edward C Burgard; Karl B Thor
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2018-06-01       Impact factor: 3.000

Review 3.  Airway receptors.

Authors:  P J Barnes
Journal:  Postgrad Med J       Date:  1989-08       Impact factor: 2.401

4.  Tachykinins potently stimulate human small bowel blood flow: a laser Doppler flowmetry study in humans.

Authors:  P T Schmidt; M Lördal; B Gazelius; P M Hellström
Journal:  Gut       Date:  2003-01       Impact factor: 23.059

5.  NK2 and NK1 receptor-mediated effects of NKA and analogs on colon, bladder, and arterial pressure in anesthetized dogs.

Authors:  Nadia M J Rupniak; Mary Katofiasc; Lesley Marson; Karl B Thor
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2017-12-26       Impact factor: 3.000

6.  Effects and interactions of sensory neuropeptides on airway microvascular leakage in guinea-pigs.

Authors:  D F Rogers; M G Belvisi; B Aursudkij; T W Evans; P J Barnes
Journal:  Br J Pharmacol       Date:  1988-12       Impact factor: 8.739

7.  Pharmacodynamic evaluation of Lys5, MeLeu9, Nle10-NKA(4-10) prokinetic effects on bladder and colon activity in acute spinal cord transected and spinally intact rats.

Authors:  F Aura Kullmann; M Katofiasc; K B Thor; Lesley Marson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2016-11-26       Impact factor: 3.000

8.  Effect of passive sensitization on the mechanical activity of human isolated bronchial smooth muscle induced by substance P, neurokinin A and VIP.

Authors:  A Ben-Jebria; R Marthan; M Rossetti; J P Savineau
Journal:  Br J Pharmacol       Date:  1993-05       Impact factor: 8.739

9.  Neurokinin A-induced contraction of guinea-pig isolated trachea: potentiation by hepoxilins.

Authors:  O Laneuville; R Couture; C R Pace-Asciak
Journal:  Br J Pharmacol       Date:  1992-11       Impact factor: 8.739

10.  Bronchodilatation by tachykinins and capsaicin in the mouse main bronchus.

Authors:  S Manzini
Journal:  Br J Pharmacol       Date:  1992-04       Impact factor: 8.739
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