Jie Li1, Qiuyuan Zhu1, Hanzhi Wang1, Cong Han1, Qunyan Zhou1, Hefeng Huang1, Minyue Dong2. 1. Women's Hospital, School of Medicine, Zhejiang University, Key Laboratory of Reproductive Genetics, Ministry of Education, China. 2. Women's Hospital, School of Medicine, Zhejiang University, Key Laboratory of Reproductive Genetics, Ministry of Education, China. Electronic address: mydong.cn@hotmail.com.
Abstract
BACKGROUND: Serum pre-adipocyte factor-1 (pref-1) is an inhibitor of adipocyte differentiation that increases in small for gestational age fetuses. It plays a role in adipose metabolism and is associated with an increased risk of metabolic diseases in adulthood. We hypothesized that preadipocyte factor-1 (pref-1) concentration is altered in fetuses born to women with gestational diabetes mellitus (GDM). METHODS: Umbilical cord blood pref-1 concentrations were determined by enzyme-linked immunosorbant assay in 37 fetuses from pregnancies complicated by GDM and 45 fetuses from normal pregnancies. RESULTS: Serum pref-1 concentrations were significantly lower in fetuses of women with GDM compared to normal pregnancies (16.12±6.48 vs. 22.09±7.22 μg/l, P=0.001). Birth weight was significantly higher in GDM fetuses compared to normal pregnancies (3567±544 vs. 3253±370 g, P=0.003). CONCLUSIONS: Pregnancies complicated by GDM have decreased fetal pref-1 concentrations compared to normal pregnancies. These differences may be significant in terms of their later development of metabolic conditions.
BACKGROUND: Serum pre-adipocyte factor-1 (pref-1) is an inhibitor of adipocyte differentiation that increases in small for gestational age fetuses. It plays a role in adipose metabolism and is associated with an increased risk of metabolic diseases in adulthood. We hypothesized that preadipocyte factor-1 (pref-1) concentration is altered in fetuses born to women with gestational diabetes mellitus (GDM). METHODS: Umbilical cord blood pref-1 concentrations were determined by enzyme-linked immunosorbant assay in 37 fetuses from pregnancies complicated by GDM and 45 fetuses from normal pregnancies. RESULTS: Serum pref-1 concentrations were significantly lower in fetuses of women with GDM compared to normal pregnancies (16.12±6.48 vs. 22.09±7.22 μg/l, P=0.001). Birth weight was significantly higher in GDM fetuses compared to normal pregnancies (3567±544 vs. 3253±370 g, P=0.003). CONCLUSIONS: Pregnancies complicated by GDM have decreased fetal pref-1 concentrations compared to normal pregnancies. These differences may be significant in terms of their later development of metabolic conditions.
Authors: Clive J Petry; Keith A Burling; Peter Barker; Ieuan A Hughes; Ken K Ong; David B Dunger Journal: J Clin Endocrinol Metab Date: 2021-05-13 Impact factor: 5.958