Liya Gong1, Feifei Yuan1, Jianhua Teng2, Xue Li1, Sining Zheng1, Liqun Lin1, Haoyuan Deng1, Guansheng Ma3, Changhao Sun1, Ying Li4. 1. Departments of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, China. 2. Departments of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, China; Institute for Tuberculosis Control and Prevention of Harbin, Harbin, China. 3. National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing, China. 4. Departments of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, China. Electronic address: liying_helen@163.com.
Abstract
OBJECTIVE: To assess the effect of a weight-loss program on improving iron status in overweight and obese school-aged children. STUDY DESIGN: The data were analyzed in overweight and obese children (7-11 years of age; 114 girls and 212 boys) with body mass index-for-age z-scores (BAZ) >1 from a weight-loss program. Schools were randomly divided into 2 groups: intervention and control. Children in the intervention group underwent a 1-year, nutrition-based comprehensive intervention weight-loss program. Anthropometric, dietary intake, and physical activity data were collected at baseline and follow-up (1 year). Iron status and inflammatory markers were assessed within a month. RESULTS: In the intervention group, BAZ decreased more than that in the control group (-0.4 ± 0.7 vs -0.1 ± 0.6, P < .0001); and iron profiles and inflammation status were improved at follow-up. In multivariable linear regression models, a greater decrease of BAZ and inflammation factors predicted a better improvement of iron status. After adjustment of ΔBAZ, ΔC-reactive protein was significantly associated with Δserum ferritin (β: 1.89; 95% CI, 0.70-3.09; P = .002) and Δsoluble transferrin receptor (β: 0.88; 95% CI, 0.16-0.59; P = .017); Δinterleukin-6 was significantly associated with Δserum ferritin (β: 1.22; 95% CI, 0.64-1.79; P < .0001). CONCLUSIONS:Iron status and inflammation were improved by weight reduction. The improvement in inflammatory markers during weight reduction was independently associated with improvements of iron status. Crown
RCT Entities:
OBJECTIVE: To assess the effect of a weight-loss program on improving iron status in overweight and obese school-aged children. STUDY DESIGN: The data were analyzed in overweight and obesechildren (7-11 years of age; 114 girls and 212 boys) with body mass index-for-age z-scores (BAZ) >1 from a weight-loss program. Schools were randomly divided into 2 groups: intervention and control. Children in the intervention group underwent a 1-year, nutrition-based comprehensive intervention weight-loss program. Anthropometric, dietary intake, and physical activity data were collected at baseline and follow-up (1 year). Iron status and inflammatory markers were assessed within a month. RESULTS: In the intervention group, BAZ decreased more than that in the control group (-0.4 ± 0.7 vs -0.1 ± 0.6, P < .0001); and iron profiles and inflammation status were improved at follow-up. In multivariable linear regression models, a greater decrease of BAZ and inflammation factors predicted a better improvement of iron status. After adjustment of ΔBAZ, ΔC-reactive protein was significantly associated with Δserum ferritin (β: 1.89; 95% CI, 0.70-3.09; P = .002) and Δsoluble transferrin receptor (β: 0.88; 95% CI, 0.16-0.59; P = .017); Δinterleukin-6 was significantly associated with Δserum ferritin (β: 1.22; 95% CI, 0.64-1.79; P < .0001). CONCLUSIONS:Iron status and inflammation were improved by weight reduction. The improvement in inflammatory markers during weight reduction was independently associated with improvements of iron status. Crown
Authors: George Paltoglou; Maria Schoina; George Valsamakis; Nicolaos Salakos; Alexandra Avloniti; Athanasios Chatzinikolaou; Alexandra Margeli; Chrysanthi Skevaki; Maria Papagianni; Christina Kanaka-Gantenbein; Ioannis Papassotiriou; George P Chrousos; Ioannis G Fatouros; George Mastorakos Journal: Endocrine Date: 2017-01-16 Impact factor: 3.633
Authors: Emma Mead; Tamara Brown; Karen Rees; Liane B Azevedo; Victoria Whittaker; Dan Jones; Joan Olajide; Giulia M Mainardi; Eva Corpeleijn; Claire O'Malley; Elizabeth Beardsmore; Lena Al-Khudairy; Louise Baur; Maria-Inti Metzendorf; Alessandro Demaio; Louisa J Ells Journal: Cochrane Database Syst Rev Date: 2017-06-22