Literature DB >> 24515936

Are chlorhexidine-containing dressings safe for use with ventricular drainages?

S Scheithauer1, M Möller, A Höllig, G Marx, S Thoröe, L Lopez-Gonzalez, M H T Reinges, S W Lemmen.   

Abstract

The purpose of this report was to assess the safety and application of chlorhexidine (CHG)-containing dressings--shown to reduce central line infection rates markedly--for external ventricular drainages (EVDs) and lumbar drainages (LDs). Cerebrospinal fluid samples of patients receiving standard dressings and CHG-containing dressing (ten each) were analyzed by high-performance liquid chromatography for the presence of CHG. The application was evaluated. CHG was not detectable in all samples. The dressings' application for EVDs and LDs worked without problems. Thus, the use of CHG-containing dressings for EVDs and LDs seems to be safe. Further studies addressing their infection reduction potential are warranted.

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Year:  2014        PMID： 24515936     DOI： 10.1007/s15010-014-0596-2

Source DB:  PubMed          Journal:  Infection        ISSN： 0300-8126            Impact factor:   3.553


  13 in total

Review 1.  Use of chlorhexidine-impregnated dressing to prevent vascular and epidural catheter colonization and infection: a meta-analysis.

Authors:  Kwok M Ho; Edward Litton
Journal:  J Antimicrob Chemother       Date:  2006-06-06       Impact factor: 5.790

2.  Sensorineural deafness following myringoplasty operations.

Authors:  P G Bicknell
Journal:  J Laryngol Otol       Date:  1971-09       Impact factor: 1.469

3.  High-performance liquid chromatographic determination of chlorhexidine in whole blood by solid-phase extraction and kinetics following an intravenous infusion in rats.

Authors:  Yuying Xue; Meng Tang; Yoko Hieda; Junko Fujihara; Koji Takayama; Hisakazu Takatsuka; Haruo Takeshita
Journal:  J Anal Toxicol       Date:  2009-03       Impact factor: 3.367

4.  Randomized controlled trial of chlorhexidine dressing and highly adhesive dressing for preventing catheter-related infections in critically ill adults.

Authors:  Jean-François Timsit; Olivier Mimoz; Bruno Mourvillier; Bertrand Souweine; Maïté Garrouste-Orgeas; Serge Alfandari; Gaétan Plantefeve; Régis Bronchard; Gilles Troche; Remy Gauzit; Marion Antona; Emmanuel Canet; Julien Bohe; Alain Lepape; Aurélien Vesin; Xavier Arrault; Carole Schwebel; Christophe Adrie; Jean-Ralph Zahar; Stéphane Ruckly; Caroline Tournegros; Jean-Christophe Lucet
Journal:  Am J Respir Crit Care Med       Date:  2012-10-04       Impact factor: 21.405

5.  Chlorhexidine-induced degeneration of adrenergic nerves.

Authors:  A Henschen; L Olson
Journal:  Acta Neuropathol       Date:  1984       Impact factor: 17.088

Review 6.  Chlorhexidine: expanding the armamentarium for infection control and prevention.

Authors:  Aaron M Milstone; Catherine L Passaretti; Trish M Perl
Journal:  Clin Infect Dis       Date:  2008-01-15       Impact factor: 9.079

7.  Chlorhexidine-impregnated sponges and less frequent dressing changes for prevention of catheter-related infections in critically ill adults: a randomized controlled trial.

Authors:  Jean-François Timsit; Carole Schwebel; Lila Bouadma; Arnaud Geffroy; Maïté Garrouste-Orgeas; Sebastian Pease; Marie-Christine Herault; Hakim Haouache; Silvia Calvino-Gunther; Brieuc Gestin; Laurence Armand-Lefevre; Véronique Leflon; Chantal Chaplain; Adel Benali; Adrien Francais; Christophe Adrie; Jean-Ralph Zahar; Marie Thuong; Xavier Arrault; Jacques Croize; Jean-Christophe Lucet
Journal:  JAMA       Date:  2009-03-25       Impact factor: 56.272

8.  Some toxic effects of lead, other metals and antibacterial agents on the nervous system--animal experiment models.

Authors:  L Olson; H Björklund; A Henschen; M Palmer; B Hoffer
Journal:  Acta Neurol Scand Suppl       Date:  1984

Review 9.  Ventriculostomy-related infections: a critical review of the literature.

Authors:  Alan P Lozier; Robert R Sciacca; Mario F Romagnoli; E Sander Connolly
Journal:  Neurosurgery       Date:  2002-07       Impact factor: 4.654

10.  Impact of an educational intervention implanted in a neurological intensive care unit on rates of infection related to external ventricular drains.

Authors:  Eduardo Fernandes Camacho; Icaro Boszczowski; Maristela Pinheiro Freire; Fernando Campos Gomes Pinto; Thais Guimaraes; Manuel Jacobsen Teixeira; Silvia Figueiredo Costa
Journal:  PLoS One       Date:  2013-02-04       Impact factor: 3.240
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