Literature DB >> 24515683

Preliminary study of the association of white-matter metabolite concentrations with disease severity in patients with Huntington's disease.

Jeffrey R Yager, Charles Gasparovic, Vincent A Magnotta, William Adams, Jess Fiedorowicz, Jane Paulsen, Ricardo Jorge, Leigh J Beglinger.   

Abstract

Proton magnetic resonance spectroscopy is used to measure several metabolites in cortical gray and white matter in patients with Huntington's disease. The preliminary results show that CAG-repeat length correlates with white-matter N-acetylaspartate concentrations, and disease severity correlates with several metabolites.

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Year:  2014        PMID： 24515683      PMCID： PMC7853078          DOI： 10.1176/appi.neuropsych.13020040

Source DB:  PubMed          Journal:  J Neuropsychiatry Clin Neurosci        ISSN： 0895-0172            Impact factor:   2.198


  15 in total

1.  Rate of caudate atrophy in presymptomatic and symptomatic stages of Huntington's disease.

Authors:  E H Aylward; A M Codori; A Rosenblatt; M Sherr; J Brandt; O C Stine; P E Barta; G D Pearlson; C A Ross
Journal:  Mov Disord       Date:  2000-05       Impact factor: 10.338

2.  Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice.

Authors:  Xiaofeng Gu; Chenjian Li; Weizheng Wei; Victor Lo; Shiaoching Gong; Shi-Hua Li; Takuji Iwasato; Shigeyoshi Itohara; Xiao-Jiang Li; Istvan Mody; Nathaniel Heintz; X William Yang
Journal:  Neuron       Date:  2005-05-05       Impact factor: 17.173

3.  Morphology of the cerebral cortex in preclinical Huntington's disease.

Authors:  Peg Nopoulos; Vincent A Magnotta; Ania Mikos; Henry Paulson; Nancy C Andreasen; Jane S Paulsen
Journal:  Am J Psychiatry       Date:  2007-09       Impact factor: 18.112

4.  Quantitative spectroscopic imaging with in situ measurements of tissue water T1, T2, and density.

Authors:  C Gasparovic; H Neeb; D L Feis; E Damaraju; H Chen; M J Doty; D M South; P G Mullins; H J Bockholt; N J Shah
Journal:  Magn Reson Med       Date:  2009-09       Impact factor: 4.668

5.  Decreased N-acetyl-aspartate/choline ratio and increased lactate in the frontal lobe of patients with Huntington's disease: a proton magnetic resonance spectroscopy study.

Authors:  L Harms; H Meierkord; G Timm; L Pfeiffer; A C Ludolph
Journal:  J Neurol Neurosurg Psychiatry       Date:  1997-01       Impact factor: 10.154

6.  CAG expansion affects the expression of mutant Huntingtin in the Huntington's disease brain.

Authors:  N Aronin; K Chase; C Young; E Sapp; C Schwarz; N Matta; R Kornreich; B Landwehrmeyer; E Bird; M F Beal
Journal:  Neuron       Date:  1995-11       Impact factor: 17.173

7.  Magnetic resonance spectroscopy and cognitive function in healthy elderly men.

Authors:  Karen J Ferguson; Alasdair M J MacLullich; Ian Marshall; Ian J Deary; John M Starr; Jonathan R Seckl; Joanna M Wardlaw
Journal:  Brain       Date:  2002-12       Impact factor: 13.501

8.  White matter volume and cognitive dysfunction in early Huntington's disease.

Authors:  Leigh J Beglinger; Peg C Nopoulos; Ricardo E Jorge; Douglas R Langbehn; Ania E Mikos; David J Moser; Kevin Duff; Robert G Robinson; Jane S Paulsen
Journal:  Cogn Behav Neurol       Date:  2005-06       Impact factor: 1.600

9.  Regional specificity of brain atrophy in Huntington's disease.

Authors:  G M Halliday; D A McRitchie; V Macdonald; K L Double; R J Trent; E McCusker
Journal:  Exp Neurol       Date:  1998-12       Impact factor: 5.330

10.  A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length.

Authors:  D R Langbehn; R R Brinkman; D Falush; J S Paulsen; M R Hayden
Journal:  Clin Genet       Date:  2004-04       Impact factor: 4.438
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