Literature DB >> 2451516

On the theoretical prediction of protein antigenic determinants from amino acid sequences.

H J Hofmann1, D Hädge.   

Abstract

The applicability range of a modified version of the Hopp-Woods model for the determination of protein antigenic determinants is estimated by comparing experimental data based on monoclonal and polyclonal antibodies. The results indicate a close correlation between the hydrophilicity of protein regions and their antigenicity. The efficiency of various hydrophilicity/hydrophobicity scales for the amino acid side chains is tested. A comment on the recognition factor concept of Fraga is given.

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Year:  1987        PMID： 2451516

Source DB:  PubMed          Journal:  Biomed Biochim Acta        ISSN： 0232-766X


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