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Literature DB >> 2451513

Potassium-channel blockers inhibit inositol trisphosphate-induced calcium release in the microsomal fractions isolated from the rat brain.

Abstract

The ionic mechanism of inositol trisphosphate (InsP3)-induced Ca2+ release was investigated in microsomes (microsomal fractions) isolated from rat brain. InsP3 stimulated Ca2+ release from microsomes incubated in media containing 100 mM-KCl. The InsP3-induced Ca2+ release was insensitive to a variety of Ca2+-channel blockers; however, the K+-channel blockers tetraethylammonium chloride (TEA; 1 mM) and 9-tetraethylammonium chloride (9-TEA; 1 mM) blocked InsP3-induced Ca2+ release. Moreover, addition of InsP3 increased 86Rb+ influx into the microsomes. The influx of 86Rb+ also was sensitive to TEA and 9-TEA. The above results suggest that InsP3-induced Ca2+ release requires an opposite flow of K+ ions, and modulation of K+ channels by TEA and 9-TEA may underlie the inhibition of InsP3-induced Ca2+ release from brain microsomes by these agents.

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Year: 1988 PMID： 2451513 PMCID： PMC1148899 DOI： 10.1042/bj2500617

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

23 in total

1. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

2. Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells.

Authors: A Fabiato; F Fabiato
Journal: J Physiol (Paris) Date: 1979

Review 3. New developments in Ca2+ channel antagonists.

Authors: R A Janis; D J Triggle
Journal: J Med Chem Date: 1983-06 Impact factor: 7.446

4. Relationship between inositol polyphosphate production and the increase of cytosolic free Ca2+ induced by vasopressin in isolated hepatocytes.

Authors: A P Thomas; J Alexander; J R Williamson
Journal: J Biol Chem Date: 1984-05-10 Impact factor: 5.157

5. Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate.

Authors: M Prentki; T J Biden; D Janjic; R F Irvine; M J Berridge; C B Wollheim
Journal: Nature Date: 1984 Jun 7-13 Impact factor: 49.962

6. The second messenger linking receptor activation to internal Ca release in liver.

Authors: G M Burgess; P P Godfrey; J S McKinney; M J Berridge; R F Irvine; J W Putney
Journal: Nature Date: 1984 May 3-9 Impact factor: 49.962

7. Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate.

Authors: H Streb; R F Irvine; M J Berridge; I Schulz
Journal: Nature Date: 1983 Nov 3-9 Impact factor: 49.962

8. myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver.

Authors: S K Joseph; A P Thomas; R J Williams; R F Irvine; J R Williamson
Journal: J Biol Chem Date: 1984-03-10 Impact factor: 5.157

9. Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol.

Authors: M J Berridge
Journal: Biochem J Date: 1983-06-15 Impact factor: 3.857

Potassium-channel blockers inhibit inositol trisphosphate-induced calcium release in the microsomal fractions isolated from the rat brain.

1. Protein measurement with the Folin phenol reagent.

2. Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells.

Review 3. New developments in Ca2+ channel antagonists.

4. Relationship between inositol polyphosphate production and the increase of cytosolic free Ca2+ induced by vasopressin in isolated hepatocytes.

5. Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate.

6. The second messenger linking receptor activation to internal Ca release in liver.

7. Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate.

8. myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver.

9. Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol.

10. Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons.

1. ABA activates multiple Ca(2+) fluxes in stomatal guard cells, triggering vacuolar K(+)(Rb(+)) release.

2. Regulation of the cerebellar inositol 1,4,5-trisphosphate receptor by univalent cations.

3. Anion channels in giant liposomes made of endoplasmic reticulum vesicles from rat exocrine pancreas.

4. Luminal Ca2+ increases the affinity of inositol 1,4,5-trisphosphate for its receptor.

5. Differences between the effects of cromakalim and nifedipine on agonist-induced responses in rabbit aorta.

6. Caffeine inhibits inositol trisphosphate-mediated liberation of intracellular calcium in Xenopus oocytes.

7. Effects of rubidium on responses to potassium channel openers in rat isolated aorta.

Review 8. Signal transduction and ion channels in guard cells.

9. Characteristics of the contractile response of rabbit aorta produced by cromakalim in calcium-free solution.

10. Tetrahexylammonium ions increase Ca2+ sensitivity of contraction of guinea-pig ileal smooth muscle.