Yu-Ching Wen1, Wei-Yu Chen2, Wei-Jiunn Lee3, Shun-Fa Yang4, Liang-Ming Lee3, Ming-Hsien Chien5. 1. Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Urology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. 2. Department of Pathology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. 3. Department of Urology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. 4. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan. 5. Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Education and Research, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. Electronic address: mhchien1976@gmail.com.
Abstract
BACKGROUND: We retrospectively investigated the relationship between immunohistochemical staining of radical prostatectomy (RP) specimens for snail and cancer recurrence. METHODS: Seventy-six patients with prostate cancer who underwent RP were enrolled, and 53 patients were ultimately collected whose cancer was pathologically defined as T2. We detected the expression of snail using tissue microarrays. The snail image score was determined by the intensity×tumor percentage, and a high score was defined as 8 (1-12 points). RESULTS: The snail image scores and Gleason score sums were correlated with recurrence-free survival according to a log-rank test (p<0.05). In a Cox proportional hazard model, only a high snail image score (≥8) (hazard ratio (HR): 3.04, p=0.036) but not a high Gleason score sum (≥7) (HR: 1.33, p=0.215), and a more-advanced pathological T stage (T2c) (HR: 1.5, p=0.461) were significantly correlated with worse recurrence-free survival. The snail image score was determined to be an independent factor for predicting prostate cancer recurrence after RP. CONCLUSION: In patients with pathological localized prostate cancer and a high snail image score in cancer tissue, adjuvant therapy might be suggested to prevent early biochemical failure.
BACKGROUND: We retrospectively investigated the relationship between immunohistochemical staining of radical prostatectomy (RP) specimens for snail and cancer recurrence. METHODS: Seventy-six patients with prostate cancer who underwent RP were enrolled, and 53 patients were ultimately collected whose cancer was pathologically defined as T2. We detected the expression of snail using tissue microarrays. The snail image score was determined by the intensity×tumor percentage, and a high score was defined as 8 (1-12 points). RESULTS: The snail image scores and Gleason score sums were correlated with recurrence-free survival according to a log-rank test (p<0.05). In a Cox proportional hazard model, only a high snail image score (≥8) (hazard ratio (HR): 3.04, p=0.036) but not a high Gleason score sum (≥7) (HR: 1.33, p=0.215), and a more-advanced pathological T stage (T2c) (HR: 1.5, p=0.461) were significantly correlated with worse recurrence-free survival. The snail image score was determined to be an independent factor for predicting prostate cancer recurrence after RP. CONCLUSION: In patients with pathological localized prostate cancer and a high snail image score in cancer tissue, adjuvant therapy might be suggested to prevent early biochemical failure.
Authors: Desirée Martínez-Martínez; María-Val Toledo Lobo; Pablo Baquero; Santiago Ropero; Javier C Angulo; Antonio Chiloeches; Marina Lasa Journal: Cancers (Basel) Date: 2021-03-08 Impact factor: 6.639