Heng Wang1, Yu Fu2, Dong Liu1, Miao Zhang1, Guoheng Zhang1, Wenbin Wu1, Shijiang Yang1, Cunjiang Li1, Hui Zhang3. 1. Department of Cardiothoracic Surgery, Xuzhou Central Hospital, Affiliated Hospital of Southeast University, Xuzhou, China. 2. Department of Scientific Research and Education, Xuzhou Central Hospital, Affiliated Hospital of Southeast University, Xuzhou, China. 3. Department of Cardiothoracic Surgery, Xuzhou Central Hospital, Affiliated Hospital of Southeast University, Xuzhou, China. Electronic address: drhuizhang@163.com.
Abstract
BACKGROUND: The Cyclooxygenase-2 (COX-2) rs20417 polymorphism has been implicated in coronary artery disease (CAD) risk, but individually published studies have shown inconsistent results. The aim of this study was to clarify the effects of COX-2 rs20417 polymorphism on CAD risk. METHODS: A systematic literature search up to October 27, 2013 was carried out in PubMed, EMBASE, and Chinese National Knowledge Infrastructure (CNKI) databases, and the references of retrieved articles were screened. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were analysed for co-dominant model (CC vs. GG), additive model (C vs. G), dominant model (CC+GC vs. GG), and recessive model (CC vs. GG+GC) to assess the association using fixed- or random-effect model. RESULTS: We identified nine articles (10 case-control studies) that included 3,439 cases and 14,182 controls for the present meta-analysis. Significant association between COX-2 rs20417 polymorphism and risk of CAD was observed in co-dominant model (OR=0.64, 95% CI=0.43-0.95, p=0.026) and recessive model (OR=0.77, 95% CI=0.61-0.97, p=0.025). Moreover, in the subgroup analysis stratified by ethnicity, significant associations were observed in Asians (OR=0.28, 95% CI=0.13-0.61, p=0.001 for CC vs. GC+GG; OR=0.24, 95% CI=0.11-0.51, p<0.001 for CC vs. GG) but not in Caucasians. CONCLUSIONS: These results suggest that COX-2 rs20417 polymorphism may contribute to CAD development, especially in Asians.
BACKGROUND: The Cyclooxygenase-2 (COX-2) rs20417 polymorphism has been implicated in coronary artery disease (CAD) risk, but individually published studies have shown inconsistent results. The aim of this study was to clarify the effects of COX-2rs20417 polymorphism on CAD risk. METHODS: A systematic literature search up to October 27, 2013 was carried out in PubMed, EMBASE, and Chinese National Knowledge Infrastructure (CNKI) databases, and the references of retrieved articles were screened. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were analysed for co-dominant model (CC vs. GG), additive model (C vs. G), dominant model (CC+GC vs. GG), and recessive model (CC vs. GG+GC) to assess the association using fixed- or random-effect model. RESULTS: We identified nine articles (10 case-control studies) that included 3,439 cases and 14,182 controls for the present meta-analysis. Significant association between COX-2rs20417 polymorphism and risk of CAD was observed in co-dominant model (OR=0.64, 95% CI=0.43-0.95, p=0.026) and recessive model (OR=0.77, 95% CI=0.61-0.97, p=0.025). Moreover, in the subgroup analysis stratified by ethnicity, significant associations were observed in Asians (OR=0.28, 95% CI=0.13-0.61, p=0.001 for CC vs. GC+GG; OR=0.24, 95% CI=0.11-0.51, p<0.001 for CC vs. GG) but not in Caucasians. CONCLUSIONS: These results suggest that COX-2rs20417 polymorphism may contribute to CAD development, especially in Asians.
Authors: Jamary Oliveira-Filho; Ana C P Ornellas; Cathy R Zhang; Luciana M B Oliveira; Théo Araújo-Santos; Valeria M Borges; Laís M G B Ventura; Francisco J F B Reis; Roque Aras; André M Fernandes; Jonathan Rosand; Steven M Greenberg; Karen L Furie; Natalia S Rost Journal: J Stroke Cerebrovasc Dis Date: 2015-05-06 Impact factor: 2.136