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Literature DB >> 24513445

Structure and function of toll-like receptor 8.

Umeharu Ohto¹, Hiromi Tanji¹, Toshiyuki Shimizu².

Abstract

Toll-like receptors (TLRs) sense pathogen-associated molecular patterns originating from invading microorganisms and initiate innate immune responses. Recent structural studies of TLR-ligand complexes have revealed the detailed molecular mechanisms by which each TLR specifically recognizes its own ligands. This review focuses on the structure of TLR8 and discusses the similarities and diversities of TLR-ligand interactions and signaling mechanisms.

Entities: Gene

Keywords: Innate immunity; Structural biology; Toll-like receptor

Mesh：

Substances：

Year: 2014 PMID： 24513445 DOI： 10.1016/j.micinf.2014.01.007

Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700

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Cited

23 in total

1. Synergistic activation of Toll-like receptor 8 by two RNA degradation products.

Authors: Matthias Geyer; Karin Pelka; Eicke Latz
Journal: Nat Struct Mol Biol Date: 2015-02 Impact factor: 15.369

Review 2. International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease.

Authors: Clare E Bryant; Selinda Orr; Brian Ferguson; Martyn F Symmons; Joseph P Boyle; Tom P Monie
Journal: Pharmacol Rev Date: 2015 Impact factor: 25.468

3. Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8.

Authors: Hiromi Tanji; Umeharu Ohto; Yuji Motoi; Takuma Shibata; Kensuke Miyake; Toshiyuki Shimizu
Journal: Proc Natl Acad Sci U S A Date: 2016-02-29 Impact factor: 11.205

Review 4. An overview of the lagomorph immune system and its genetic diversity.

Authors: Ana Pinheiro; Fabiana Neves; Ana Lemos de Matos; Joana Abrantes; Wessel van der Loo; Rose Mage; Pedro José Esteves
Journal: Immunogenetics Date: 2015-09-23 Impact factor: 2.846

Review 5. Vaccine technologies: From whole organisms to rationally designed protein assemblies.

Authors: Christopher P Karch; Peter Burkhard
Journal: Biochem Pharmacol Date: 2016-05-06 Impact factor: 5.858

6. Direct and Intestinal Epithelial Cell-Mediated Effects of TLR8 Triggering on Human Dendritic Cells, CD14⁺CD16⁺ Monocytes and γδ T Lymphocytes.

Authors: Costanza Angelini; Barbara Varano; Patrizia Puddu; Maurizio Fiori; Antonella Baldassarre; Andrea Masotti; Sandra Gessani; Lucia Conti
Journal: Front Immunol Date: 2017-12-22 Impact factor: 7.561

Structure and function of toll-like receptor 8.

1. Synergistic activation of Toll-like receptor 8 by two RNA degradation products.

Review 2. International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease.

3. Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8.

Review 4. An overview of the lagomorph immune system and its genetic diversity.

Review 5. Vaccine technologies: From whole organisms to rationally designed protein assemblies.

6. Direct and Intestinal Epithelial Cell-Mediated Effects of TLR8 Triggering on Human Dendritic Cells, CD14⁺CD16⁺ Monocytes and γδ T Lymphocytes.

Review 7. TLR-Dependent Human Mucosal Epithelial Cell Responses to Microbial Pathogens.

8. Molecular cloning and functional characterization of murine toll‑like receptor 8.

Review 9. Virtual Screening Approaches towards the Discovery of Toll-Like Receptor Modulators.

Review 10. Research progress on Toll-like receptor signal transduction and its roles in antimicrobial immune responses.

Structure and function of toll-like receptor 8.

1. Synergistic activation of Toll-like receptor 8 by two RNA degradation products.

Review 2. International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease.

3. Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8.

Review 4. An overview of the lagomorph immune system and its genetic diversity.

Review 5. Vaccine technologies: From whole organisms to rationally designed protein assemblies.

6. Direct and Intestinal Epithelial Cell-Mediated Effects of TLR8 Triggering on Human Dendritic Cells, CD14+CD16+ Monocytes and γδ T Lymphocytes.

Review 7. TLR-Dependent Human Mucosal Epithelial Cell Responses to Microbial Pathogens.

8. Molecular cloning and functional characterization of murine toll‑like receptor 8.

Review 9. Virtual Screening Approaches towards the Discovery of Toll-Like Receptor Modulators.

Review 10. Research progress on Toll-like receptor signal transduction and its roles in antimicrobial immune responses.

6. Direct and Intestinal Epithelial Cell-Mediated Effects of TLR8 Triggering on Human Dendritic Cells, CD14⁺CD16⁺ Monocytes and γδ T Lymphocytes.