OBJECTIVE: Treatment with interferon therapy for hepatitis can induce depression and/or recurrence of affective illness, which could result in cessation of interferon treatment. This article reviews treatment for interferon-induced depression, including antidepressant drugs that may diminish associated symptoms. DATA SOURCES: English-language literature with no date restrictions on the treatment of interferon-induced depression was reviewed via PubMed and MEDLINE using the key words hepatitis, interferon, hepatitis C, interferon-induced depression, pharmacotherapy of interferon-induced depression, and depression prevention. Fourteen of the most pertinent references are cited. DATA EXTRACTION: Escitalopram is the most prominently noted pharmaceutical prescribed for treating mood symptoms in hepatitis patients with interferon-induced depression. Other antidepressant medicines may have utility as well. RESULTS: Antidepressant drugs can be efficacious in diminishing mood disorders during hepatitis therapies. It remains controversial as to whether antidepressant medications can provide prophylaxis against newly developing interferon-induced depressions in individuals with no past history of a mood disorder. CONCLUSIONS: Antidepressant medicines can be effective at improving mood in patients undergoing interferon treatment for hepatitis.
OBJECTIVE: Treatment with interferon therapy for hepatitis can induce depression and/or recurrence of affective illness, which could result in cessation of interferon treatment. This article reviews treatment for interferon-induced depression, including antidepressant drugs that may diminish associated symptoms. DATA SOURCES: English-language literature with no date restrictions on the treatment of interferon-induced depression was reviewed via PubMed and MEDLINE using the key words hepatitis, interferon, hepatitis C, interferon-induced depression, pharmacotherapy of interferon-induced depression, and depression prevention. Fourteen of the most pertinent references are cited. DATA EXTRACTION: Escitalopram is the most prominently noted pharmaceutical prescribed for treating mood symptoms in hepatitispatients with interferon-induced depression. Other antidepressant medicines may have utility as well. RESULTS: Antidepressant drugs can be efficacious in diminishing mood disorders during hepatitis therapies. It remains controversial as to whether antidepressant medications can provide prophylaxis against newly developing interferon-induced depressions in individuals with no past history of a mood disorder. CONCLUSIONS: Antidepressant medicines can be effective at improving mood in patients undergoing interferon treatment for hepatitis.
Authors: Martin Schaefer; Rahul Sarkar; Viola Knop; Susanne Effenberger; Astrid Friebe; Loni Heinze; Ulrich Spengler; Thomas Schlaepfer; Jens Reimer; Peter Buggisch; Johann Ockenga; Ralph Link; Michael Rentrop; Hans Weidenbach; Gwendolyn Fromm; Klaus Lieb; Thomas F Baumert; Andreas Heinz; Thomas Discher; Konrad Neumann; Stefan Zeuzem; Thomas Berg Journal: Ann Intern Med Date: 2012-07-17 Impact factor: 25.391
Authors: Benjamin J Morasco; Muhamad Aly Rifai; Jennifer M Loftis; David W Indest; James Kelly Moles; Peter Hauser Journal: J Affect Disord Date: 2007-02-09 Impact factor: 4.839
Authors: R J de Knegt; G Bezemer; A R Van Gool; J P H Drenth; B E Hansen; H A Droogleever Fortuyn; C J Weegink; M W Hengeveld; H L A Janssen Journal: Aliment Pharmacol Ther Date: 2011-10-17 Impact factor: 8.171
Authors: C L Raison; B J Woolwine; M F Demetrashvili; A S Borisov; R Weinreib; J P Staab; J M Zajecka; C J Bruno; M A Henderson; J F Reinus; D L Evans; G M Asnis; A H Miller Journal: Aliment Pharmacol Ther Date: 2007-05-15 Impact factor: 8.171