Literature DB >> 24511389

Novel therapeutic delivery approaches in development for pediatric gliomas.

Katherine E Warren.   

Abstract

Pediatric gliomas are a heterogeneous group of diseases, ranging from relatively benign pilocytic astrocytomas with >90% 5-year survival, to glioblastomas and diffuse intrinsic pontine gliomas with <20% 5-year survival. Chemotherapy plays an important role in the management of these tumors, particularly in low-grade gliomas, but many high-grade tumors are resistant to chemotherapy. A major obstacle and contributor to this resistance is the blood–brain barrier, which protects the CNS by limiting entry of potential toxins, including chemotherapeutic agents. Several novel delivery approaches that circumvent the blood–brain barrier have been developed, including some currently in clinical trials. This review describes several of these novel approaches to improve delivery of chemotherapeutic agents to their site of action at the tumor, in attempts to improve their efficacy and the prognosis of children with this disease.

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Year:  2013        PMID： 24511389      PMCID： PMC3912872          DOI： 10.2217/cns.13.37

Source DB:  PubMed          Journal:  CNS Oncol        ISSN： 2045-0907


  66 in total

1.  Imaging-guided convection-enhanced delivery and gene therapy of glioblastoma.

Authors:  Juergen Voges; Regina Reszka; Axel Gossmann; Claus Dittmar; Raphaela Richter; Guido Garlip; Lutz Kracht; Heinz H Coenen; Volker Sturm; Karl Wienhard; Wolf-Dieter Heiss; Andreas H Jacobs
Journal:  Ann Neurol       Date:  2003-10       Impact factor: 10.422

Review 2.  Direct nose to brain drug delivery via integrated nerve pathways bypassing the blood-brain barrier: an excellent platform for brain targeting.

Authors:  Chandrakantsing Vijaysing Pardeshi; Veena Shailendra Belgamwar
Journal:  Expert Opin Drug Deliv       Date:  2013-04-16       Impact factor: 6.648

3.  Convection-enhanced delivery of macromolecules in the brain.

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Journal:  Proc Natl Acad Sci U S A       Date:  1994-03-15       Impact factor: 11.205

4.  The potential for complete and durable response in nonglial primary brain tumors in children and young adults with enhanced chemotherapy delivery.

Authors:  S A Dahlborg; A Petrillo; J R Crossen; S Roman-Goldstein; N D Doolittle; K H Fuller; E A Neuwelt
Journal:  Cancer J Sci Am       Date:  1998 Mar-Apr

5.  Carboplatin and vincristine chemotherapy for children with newly diagnosed progressive low-grade gliomas.

Authors:  R J Packer; J Ater; J Allen; P Phillips; R Geyer; H S Nicholson; R Jakacki; E Kurczynski; M Needle; J Finlay; G Reaman; J M Boyett
Journal:  J Neurosurg       Date:  1997-05       Impact factor: 5.115

6.  Vascular distribution of glioblastoma multiforme at diagnosis.

Authors:  K Yohay; D S Wolf; L J Aronson; M Duus; E R Melhem; K J Cohen
Journal:  Interv Neuroradiol       Date:  2013-03-04       Impact factor: 1.610

7.  Implanted carmustine wafers followed by concomitant radiochemotherapy to treat newly diagnosed malignant gliomas: prospective, observational, multicenter study on 92 cases.

Authors:  Julien Duntze; Claude-Fabien Litré; Christophe Eap; Etienne Théret; Adeline Debreuve; Nicolas Jovenin; Emmanuèle Lechapt-Zalcman; Philippe Metellus; Philippe Colin; Jean-Sébastien Guillamo; Evelyne Emery; Philippe Menei; Pascal Rousseaux; Philippe Peruzzi
Journal:  Ann Surg Oncol       Date:  2012-12-02       Impact factor: 5.344

Review 8.  Which drug or drug delivery system can change clinical practice for brain tumor therapy?

Authors:  Tali Siegal
Journal:  Neuro Oncol       Date:  2013-03-15       Impact factor: 12.300

9.  Diffuse intrinsic pontine glioma: poised for progress.

Authors:  Katherine E Warren
Journal:  Front Oncol       Date:  2012-12-28       Impact factor: 6.244

10.  In vitro drug response and efflux transporters associated with drug resistance in pediatric high grade glioma and diffuse intrinsic pontine glioma.

Authors:  Susanna J E Veringa; Dennis Biesmans; Dannis G van Vuurden; Marc H A Jansen; Laurine E Wedekind; Ilona Horsman; Pieter Wesseling; William Peter Vandertop; David P Noske; GertJan J L Kaspers; Esther Hulleman
Journal:  PLoS One       Date:  2013-04-29       Impact factor: 3.240
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  11 in total

1.  Pharmacokinetic/Pharmacodynamics Modeling of Drug-Loaded PLGA Nanoparticles Targeting Heterogeneously Vascularized Tumor Tissue.

Authors:  Hunter A Miller; Hermann B Frieboes
Journal:  Pharm Res       Date:  2019-11-26       Impact factor: 4.200

2.  Plasma and cerebrospinal fluid pharmacokinetics of select chemotherapeutic agents following intranasal delivery in a non-human primate model.

Authors:  James C League-Pascual; Cynthia M Lester-McCully; Shaefali Shandilya; Lukas Ronner; Louis Rodgers; Rafael Cruz; Cody J Peer; William D Figg; Katherine E Warren
Journal:  J Neurooncol       Date:  2017-03-13       Impact factor: 4.130

Review 3.  Pediatric high-grade glioma: current molecular landscape and therapeutic approaches.

Authors:  Steve Braunstein; David Raleigh; Ranjit Bindra; Sabine Mueller; Daphne Haas-Kogan
Journal:  J Neurooncol       Date:  2017-03-29       Impact factor: 4.130

Review 4.  Glioblastoma: Current Status, Emerging Targets, and Recent Advances.

Authors:  Amandeep Thakur; Chetna Faujdar; Ram Sharma; Sachin Sharma; Basant Malik; Kunal Nepali; Jing Ping Liou
Journal:  J Med Chem       Date:  2022-07-05       Impact factor: 8.039

5.  An interdisciplinary computational/experimental approach to evaluate drug-loaded gold nanoparticle tumor cytotoxicity.

Authors:  Louis T Curtis; Christopher G England; Min Wu; John Lowengrub; Hermann B Frieboes
Journal:  Nanomedicine (Lond)       Date:  2016-02       Impact factor: 5.307

6.  Enhanced uptake and transport of PLGA-modified nanoparticles in cervical cancer.

Authors:  Lee B Sims; Louis T Curtis; Hermann B Frieboes; Jill M Steinbach-Rankins
Journal:  J Nanobiotechnology       Date:  2016-04-22       Impact factor: 10.435

7.  Effective Drug Delivery in Diffuse Intrinsic Pontine Glioma: A Theoretical Model to Identify Potential Candidates.

Authors:  Fatma E El-Khouly; Dannis G van Vuurden; Thom Stroink; Esther Hulleman; Gertjan J L Kaspers; N Harry Hendrikse; Sophie E M Veldhuijzen van Zanten
Journal:  Front Oncol       Date:  2017-10-30       Impact factor: 6.244

8.  Characterization of the Blood-Brain Barrier Integrity and the Brain Transport of SN-38 in an Orthotopic Xenograft Rat Model of Diffuse Intrinsic Pontine Glioma.

Authors:  Catarina Chaves; Xavier Declèves; Meryam Taghi; Marie-Claude Menet; Joelle Lacombe; Pascale Varlet; Nagore G Olaciregui; Angel M Carcaboso; Salvatore Cisternino
Journal:  Pharmaceutics       Date:  2020-04-27       Impact factor: 6.321

9.  Nasal delivery of nanoliposome-encapsulated ferric ammonium citrate can increase the iron content of rat brain.

Authors:  Xueling Guo; Hong Zheng; Yuetong Guo; Yan Wang; Gregory J Anderson; Yunzhe Ci; Peng Yu; Lina Geng; Yan-Zhong Chang
Journal:  J Nanobiotechnology       Date:  2017-06-02       Impact factor: 10.435

Review 10.  The Integration of Biology Into the Treatment of Diffuse Intrinsic Pontine Glioma: A Review of the North American Clinical Trial Perspective.

Authors:  Jessica Clymer; Mark W Kieran
Journal:  Front Oncol       Date:  2018-05-18       Impact factor: 6.244
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