| Literature DB >> 24511387 |
Abstract
Lanthanide bioprobes and bioconjugates are ideal luminescent stains in view of their low propensity to photobleaching, sharp emission lines and long excited state lifetimes permitting time-resolved detection for enhanced sensitivity. We show here how the interplay between physical, chemical and biochemical properties allied to microfluidics engineering leads to self-assembled dinuclear lanthanide luminescent probes illuminating live cells and selectively detecting biomarkers expressed by cancerous human breast cells.Entities:
Keywords: bioconjugate; cell imaging; lanthanide; luminescent bioprobe; self-assembly; time-resolved luminescence microscopy
Year: 2013 PMID: 24511387 PMCID: PMC3915826 DOI: 10.1098/rsfs.2013.0032
Source DB: PubMed Journal: Interface Focus ISSN: 2042-8898 Impact factor: 3.906