BACKGROUND/AIM: Human papillomavirus (HPV) infection has been considered a potential risk factor for the development of oral tongue squamous cell carcinoma (SCC). The purpose of the present study was to investigate HPV infection and high-risk HPV E6/E7 mRNA expression in SCC of the oral tongue in 53 Greek patients. MATERIALS AND METHODS: Fifty-three biopsies were collected from patients with SCC of the oral tongue and tested for HPV DNA and E6/E7 mRNA expression. RESULTS: The overall prevalence of HPV DNA was 11.3% (6/53), while high-risk HPV DNA was found in 7.5% (4/53) of SCC of the oral tongue. E6/E7 mRNA expression was observed in 9.4% (5/53) samples examined. HPV 16 was the commonest genotype identified by both DNA and RNA assays. A total of 28.3% (15/53) of the patients were non-smokers and non-drinkers. HPV infection was strongly associated with abstinence from tobacco and alcohol (p=0.013). CONCLUSION: The presence of high-risk HPV E6/E7 mRNA expression suggests that HPV may be implicated in the pathogenesis of SCC of the oral tongue.
BACKGROUND/AIM: Human papillomavirus (HPV) infection has been considered a potential risk factor for the development of oral tongue squamous cell carcinoma (SCC). The purpose of the present study was to investigate HPV infection and high-risk HPVE6/E7 mRNA expression in SCC of the oral tongue in 53 Greek patients. MATERIALS AND METHODS: Fifty-three biopsies were collected from patients with SCC of the oral tongue and tested for HPV DNA and E6/E7 mRNA expression. RESULTS: The overall prevalence of HPV DNA was 11.3% (6/53), while high-risk HPV DNA was found in 7.5% (4/53) of SCC of the oral tongue. E6/E7 mRNA expression was observed in 9.4% (5/53) samples examined. HPV 16 was the commonest genotype identified by both DNA and RNA assays. A total of 28.3% (15/53) of the patients were non-smokers and non-drinkers. HPV infection was strongly associated with abstinence from tobacco and alcohol (p=0.013). CONCLUSION: The presence of high-risk HPVE6/E7 mRNA expression suggests that HPV may be implicated in the pathogenesis of SCC of the oral tongue.
Authors: P Chandrani; V Kulkarni; P Iyer; P Upadhyay; R Chaubal; P Das; R Mulherkar; R Singh; A Dutt Journal: Br J Cancer Date: 2015-05-14 Impact factor: 7.640
Authors: David L McCormick; Thomas L Horn; William D Johnson; Xinjian Peng; Ronald A Lubet; Vernon E Steele Journal: PLoS One Date: 2015-10-30 Impact factor: 3.240
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Authors: Frans J Mulder; Damiana D C G Pierssens; Laura W J Baijens; Bernd Kremer; Ernst-Jan M Speel Journal: Head Neck Date: 2020-10-23 Impact factor: 3.147