| Literature DB >> 24510857 |
Masafumi Ihara1, Akihiko Taguchi, Takakuni Maki, Kazuo Washida, Hidekazu Tomimoto.
Abstract
Vascular dementia or vascular cognitive impairment occurs as a result of persistently compromised blood flow to the brain and represents the second most common type of dementia after Alzheimer's disease. In order to investigate its underlying mechanisms, a mouse model of chronic cerebral hypoperfusion has been developed, which involves the narrowing of the bilateral common carotid arteries with newly designed microcoils. This mouse model provides a unique platform to investigate the mechanisms of angiogenesis following chronic cerebral hypoperfusion and to explore potential drugs or cell therapies designed to enhance angiogenesis as a preclinical step toward developing novel treatments for dementia of vascular origin.Entities:
Mesh：
Year: 2014 PMID： 24510857 DOI： 10.1007/978-1-4939-0320-7_8
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745