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Literature DB >> 24510075

Role of mitochondrial calcium uniporter in regulating mitochondrial fission in the cerebral cortexes of living rats.

Nan Liang¹, Peng Wang, Shilei Wang, Shuhong Li, Yu Li, Jinying Wang, Min Wang.

Abstract

The mitochondrial calcium uniporter (MCU) transports Ca2+ from the cytoplasm to the mitochondrial matrix and thus maintains Ca2+ homeostasis. Previous studies have reported that inhibition of MCU by ruthenium red (RR) protects the brain from ischemia/reperfusion (I/R) injury and that mitochondrial fission plays an important role in I/R injury. However, it is still not known whether MCU affects mitochondrial fission. In the present study, treatment with RR was found to decrease the concentration of free calcium in the mitochondria, calcineurin enzyme activity and dynamin-related protein 1 expression, and treatment with spermine was found to have the opposite effect in organisms subjected to occlusion of the middle cerebral artery lasting 2 h followed by 24 h reperfusion. These results indicate that MCU may be related to mitochondrial fission via modulating mitochondrial Ca2+ uptake and this relationship between MCU and mitochondrial fission may protect the brain from I/R injury.

Entities: Chemical Disease Gene Species

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Year: 2014 PMID： 24510075 DOI： 10.1007/s00702-014-1166-6

Source DB: PubMed Journal: J Neural Transm (Vienna) ISSN： 0300-9564 Impact factor: 3.575

29 in total

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Journal: Mol Biol Cell Date: 2001-08 Impact factor: 4.138

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Journal: Dev Cell Date: 2001-10 Impact factor: 12.270

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Journal: Trends Cell Biol Date: 2007-10-23 Impact factor: 20.808

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Authors: Masao Saotome; Dzhamilja Safiulina; György Szabadkai; Sudipto Das; Asa Fransson; Pontus Aspenstrom; Rosario Rizzuto; György Hajnóczky
Journal: Proc Natl Acad Sci U S A Date: 2008-12-19 Impact factor: 11.205

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Journal: Proc Natl Acad Sci U S A Date: 2008-10-06 Impact factor: 11.205

10. Calcium input frequency, duration and amplitude differentially modulate the relative activation of calcineurin and CaMKII.

Authors: Lu Li; Melanie I Stefan; Nicolas Le Novère
Journal: PLoS One Date: 2012-09-04 Impact factor: 3.240

9 in total

1. Mdivi-1 Alleviates Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats, Possibly via Inhibition of Drp1-Activated Mitochondrial Fission and Oxidative Stress.

Authors: Pei Wu; Yuchen Li; Shiyi Zhu; Chunlei Wang; Jiaxing Dai; Guang Zhang; Bingjie Zheng; Shancai Xu; Ligang Wang; Tongyu Zhang; PeiQuan Zhou; John H Zhang; Huaizhang Shi
Journal: Neurochem Res Date: 2017-02-16 Impact factor: 3.996

2. Role of Mitochondrial Calcium Uniporter in Early Brain Injury After Experimental Subarachnoid Hemorrhage.

Authors: Huiying Yan; Dingding Zhang; Shuangying Hao; Kuanyu Li; Chun-Hua Hang
Journal: Mol Neurobiol Date: 2014-11-05 Impact factor: 5.590

3. Gadolinium and ruthenium red attenuate remote hind limb preconditioning-induced cardioprotection: possible role of TRP and especially TRPV channels.

Authors: Puneet Kaur Randhawa; Amteshwar Singh Jaggi
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2016-04-27 Impact factor: 3.000

4. The Effect of Propofol on Mitochondrial Fission during Oxygen-Glucose Deprivation and Reperfusion Injury in Rat Hippocampal Neurons.

Authors: Haibin Wang; Shengfa Zheng; Maodong Liu; Changxin Jia; Shilei Wang; Xue Wang; Sha Xue; Yunliang Guo
Journal: PLoS One Date: 2016-10-27 Impact factor: 3.240

Role of mitochondrial calcium uniporter in regulating mitochondrial fission in the cerebral cortexes of living rats.

Review 1. Cell death: critical control points.

Review 2. Behavior of mitochondria in the living cell.

Review 3. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death.

4. Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells.

5. The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis.

Review 6. Regulation of mitochondrial fusion and division.

7. Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase.

8. Reversible middle cerebral artery occlusion without craniectomy in rats.

9. Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria.

10. Calcium input frequency, duration and amplitude differentially modulate the relative activation of calcineurin and CaMKII.

1. Mdivi-1 Alleviates Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats, Possibly via Inhibition of Drp1-Activated Mitochondrial Fission and Oxidative Stress.

2. Role of Mitochondrial Calcium Uniporter in Early Brain Injury After Experimental Subarachnoid Hemorrhage.

3. Gadolinium and ruthenium red attenuate remote hind limb preconditioning-induced cardioprotection: possible role of TRP and especially TRPV channels.

4. The Effect of Propofol on Mitochondrial Fission during Oxygen-Glucose Deprivation and Reperfusion Injury in Rat Hippocampal Neurons.

Review 5. The Regulation of Tumor Cell Invasion and Metastasis by Endoplasmic Reticulum-to-Mitochondrial Ca²⁺ Transfer.

6. Pathological consequences of MICU1 mutations on mitochondrial calcium signalling and bioenergetics.

Review 7. New insights into the role of mitochondrial calcium homeostasis in cell migration.

8. Role of mitochondrial calcium uniporter-mediated Ca²⁺ and iron accumulation in traumatic brain injury.

Review 9. MicroRNAs Regulate Mitochondrial Function in Cerebral Ischemia-Reperfusion Injury.

Review 1. Cell death: critical control points.

Review 2. Behavior of mitochondria in the living cell.

Review 3. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death.

Review 6. Regulation of mitochondrial fusion and division.

Review 5. The Regulation of Tumor Cell Invasion and Metastasis by Endoplasmic Reticulum-to-Mitochondrial Ca2+ Transfer.

Review 7. New insights into the role of mitochondrial calcium homeostasis in cell migration.

Review 9. MicroRNAs Regulate Mitochondrial Function in Cerebral Ischemia-Reperfusion Injury.

Review 5. The Regulation of Tumor Cell Invasion and Metastasis by Endoplasmic Reticulum-to-Mitochondrial Ca²⁺ Transfer.