Malgorzata Mossakowska1, Katarzyna Broczek2, Katarzyna Wieczorowska-Tobis3, Alicja Klich-Rączka4, Marta Jonas5, Eliza Pawlik-Pachucka6, Krzysztof Safranow7, Jacek Kuznicki8, Monika Puzianowska-Kuznicka9. 1. PolStu Project, International Institute of Molecular and Cell Biology, Warsaw, Poland. 2. Department of Geriatrics, Medical University of Warsaw, Poland. 3. Department of Palliative Medicine, Poznan University of Medical Sciences, Poland. 4. Department of Internal Medicine and Geriatrics, Faculty of Medicine, Jagiellonian University, Cracow, Poland. 5. Department of Human Epigenetics, Mossakowski Medical Research Centre, Warsaw, Poland. 6. Department of Human Epigenetics, Mossakowski Medical Research Centre, Warsaw, Poland. Department of Geriatrics and Gerontology, Medical Centre of Postgraduate Education, Warsaw, Poland. 7. Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland. 8. Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology, Warsaw, Poland. 9. Department of Human Epigenetics, Mossakowski Medical Research Centre, Warsaw, Poland. Department of Geriatrics and Gerontology, Medical Centre of Postgraduate Education, Warsaw, Poland. mpuzianowska@wum.edu.pl.
Abstract
BACKGROUND: Clinical and biochemical predictors of extreme longevity would be useful in geriatric practice but have still not been clearly defined. METHODS: To identify the best nongenetic predictors of survival in centenarians, we examined 340 individuals aged 100+ years. A detailed questionnaire was completed, and comprehensive geriatric assessment and blood analyses were performed. Survival of study participants was checked annually over the period of 10 years. RESULTS: In the univariate Cox proportional hazards model, a longer survival of centenarians was correlated with a higher adjusted Mini-Mental State Examination (MMSE(adj)) score (p < .000001), higher Activities of Daily Living (ADL) and adjusted Instrumental Activities of Daily Living (IADL(adj)) scores (p < .000001 and p = .00008, respectively), and younger age at the time of testing (p = .005). Blood pressure, lipid profile, and C-reactive protein and hemoglobin concentrations were not associated with survival. Multivariate analysis including age, sex, and the MMSE(adj) and ADL scores showed that both MMSE(adj) and ADL predicted survival (HR = 0.978 per each MMSE(adj) point, 95% CI: 0.964-0.993, p = .004; HR = 0.900 per each ADL point, 95% CI: 0.842-0.962, p = .002, respectively). In multivariate analysis with the ADL score substituted by the IADL(adj) score, the only predictor of survival was MMSE(adj) (HR = 0.973 per each MMSE(adj) point, 95% CI: 0.958-0.988, p = .0006). CONCLUSIONS: Cognitive and functional performances are predictors of survival in centenarians.
BACKGROUND: Clinical and biochemical predictors of extreme longevity would be useful in geriatric practice but have still not been clearly defined. METHODS: To identify the best nongenetic predictors of survival in centenarians, we examined 340 individuals aged 100+ years. A detailed questionnaire was completed, and comprehensive geriatric assessment and blood analyses were performed. Survival of study participants was checked annually over the period of 10 years. RESULTS: In the univariate Cox proportional hazards model, a longer survival of centenarians was correlated with a higher adjusted Mini-Mental State Examination (MMSE(adj)) score (p < .000001), higher Activities of Daily Living (ADL) and adjusted Instrumental Activities of Daily Living (IADL(adj)) scores (p < .000001 and p = .00008, respectively), and younger age at the time of testing (p = .005). Blood pressure, lipid profile, and C-reactive protein and hemoglobin concentrations were not associated with survival. Multivariate analysis including age, sex, and the MMSE(adj) and ADL scores showed that both MMSE(adj) and ADL predicted survival (HR = 0.978 per each MMSE(adj) point, 95% CI: 0.964-0.993, p = .004; HR = 0.900 per each ADL point, 95% CI: 0.842-0.962, p = .002, respectively). In multivariate analysis with the ADL score substituted by the IADL(adj) score, the only predictor of survival was MMSE(adj) (HR = 0.973 per each MMSE(adj) point, 95% CI: 0.958-0.988, p = .0006). CONCLUSIONS: Cognitive and functional performances are predictors of survival in centenarians.
Authors: Kristine E Ensrud; Li-Yung Lui; Misti L Paudel; John T Schousboe; Allyson M Kats; Jane A Cauley; Charles E McCulloch; Kristine Yaffe; Peggy M Cawthon; Teresa A Hillier; Brent C Taylor Journal: J Gerontol A Biol Sci Med Sci Date: 2015-12-28 Impact factor: 6.053
Authors: Jan Szewieczek; Jan Dulawa; Tomasz Francuz; Katarzyna Legierska; Beata Hornik; Iwona Włodarczyk-Sporek; Magdalena Janusz-Jenczeń; Agnieszka Batko-Szwaczka Journal: Age (Dordr) Date: 2014-12-23
Authors: Jan Szewieczek; Tomasz Francuz; Jan Dulawa; Katarzyna Legierska; Beata Hornik; Iwona Włodarczyk; Magdalena Janusz-Jenczeń; Agnieszka Batko-Szwaczka Journal: Age (Dordr) Date: 2015-08-21