Literature DB >> 24509706

N-Methyl and peptoid scans of an autoinducing peptide reveal new structural features required for inhibition and activation of AgrC quorum sensing receptors in Staphylococcus aureus.

Yftah Tal-Gan1, Danielle M Stacy, Helen E Blackwell.   

Abstract

We report the first N-methyl and peptoid residue scans of a full-length autoinducing peptide (AIP), AIP-III, used by Staphylococcus aureus for quorum sensing (QS). Biological evaluation of these AIP-III analogues uncovered new features of the AIP-III scaffold that can be tuned to develop chemical probes of QS in all four groups of S. aureus (I-IV).

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 24509706     DOI： 10.1039/c4cc00117f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  14 in total

1.  Unveiling the Importance of Amide Protons in CSP:ComD Interactions in Streptococcus pneumoniae.

Authors:  Bimal Koirala; Naiya R Phillips; Yftah Tal-Gan
Journal:  ACS Med Chem Lett       Date:  2019-04-30       Impact factor: 4.345

2.  Highly Stable, Amide-Bridged Autoinducing Peptide Analogues that Strongly Inhibit the AgrC Quorum Sensing Receptor in Staphylococcus aureus.

Authors:  Yftah Tal-Gan; Monika Ivancic; Gabriel Cornilescu; Tian Yang; Helen E Blackwell
Journal:  Angew Chem Int Ed Engl       Date:  2016-06-08       Impact factor: 15.336

3.  Truncated Autoinducing Peptides as Antagonists of Staphylococcus lugdunensis Quorum Sensing.

Authors:  Christopher P Gordon; Shondra D Olson; Jessica L Lister; Jeffrey S Kavanaugh; Alexander R Horswill
Journal:  J Med Chem       Date:  2016-09-15       Impact factor: 7.446

4.  Simplified AIP-II Peptidomimetics Are Potent Inhibitors of Staphylococcus aureus AgrC Quorum Sensing Receptors.

Authors:  Joseph K Vasquez; Yftah Tal-Gan; Gabriel Cornilescu; Kimberly A Tyler; Helen E Blackwell
Journal:  Chembiochem       Date:  2017-01-20       Impact factor: 3.164

5.  Conformational Switch to a β-Turn in a Staphylococcal Quorum Sensing Signal Peptide Causes a Dramatic Increase in Potency.

Authors:  Joseph K Vasquez; Korbin H J West; Tian Yang; Thomas J Polaske; Gabriel Cornilescu; Marco Tonelli; Helen E Blackwell
Journal:  J Am Chem Soc       Date:  2020-01-02       Impact factor: 15.419

6.  Simplified Autoinducing Peptide Mimetics with Single-Nanomolar Activity Against the Staphylococcus aureus AgrC Quorum Sensing Receptor.

Authors:  Joseph K Vasquez; Helen E Blackwell
Journal:  ACS Infect Dis       Date:  2019-03-13       Impact factor: 5.084

7.  Structure-Function Analyses of a Staphylococcus epidermidis Autoinducing Peptide Reveals Motifs Critical for AgrC-type Receptor Modulation.

Authors:  Tian Yang; Yftah Tal-Gan; Alexandra E Paharik; Alexander R Horswill; Helen E Blackwell
Journal:  ACS Chem Biol       Date:  2016-05-18       Impact factor: 5.100

Review 8.  Investigational therapies targeting quorum-sensing for the treatment of Staphylococcus aureus infections.

Authors:  Burhan A Khan; Anthony J Yeh; Gordon Y C Cheung; Michael Otto
Journal:  Expert Opin Investig Drugs       Date:  2015-02-23       Impact factor: 6.206

Review 9.  Regulation of Virulence in Staphylococcus aureus: Molecular Mechanisms and Remaining Puzzles.

Authors:  Boyuan Wang; Tom W Muir
Journal:  Cell Chem Biol       Date:  2016-02-18       Impact factor: 8.116

10.  Characterization of structural elements in native autoinducing peptides and non-native analogues that permit the differential modulation of AgrC-type quorum sensing receptors in Staphylococcus aureus.

Authors:  Yftah Tal-Gan; Monika Ivancic; Gabriel Cornilescu; Helen E Blackwell
Journal:  Org Biomol Chem       Date:  2015-09-29       Impact factor: 3.876
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.