| Literature DB >> 24509230 |
Raphaël Borie1, Martine Antoine2, Jacques Cadranel3, Marie Wislez3.
Abstract
This review will describe the current knowledge in the pathophysiology, diagnosis, prognosis and treatment of pulmonary MALT (Mucosa Associated Lymphoid Tissue) lymphoma. Pulmonary MALT lymphomas are low-grade B cell lymphoma and are the most frequent lymphomas arising from the lung. Tumour cells arise from mucosa associated lymphoid tissue. Unlike other sites, no pathogen has been associated with pulmonary location of MALT lymphoma. However addictive translocations involving the MALT1 gene are frequently evidenced Patients are frequently asymptomatic and present with a chronic alveolar opacity. Diagnosis requires histology that may be retrieved by minimally invasive procedures during bronchial endoscopy or by CT scan guided percutaneous biopsies. Prognosis is good and treatment may vary with abstention, surgery, radiotherapy, immunotherapy or chemotherapy.Entities:
Keywords: chronic alveolar opacity; clonality; oncogene; translocation
Mesh:
Year: 2014 PMID: 24509230 DOI: 10.1684/bdc.2014.1885
Source DB: PubMed Journal: Bull Cancer ISSN: 0007-4551 Impact factor: 1.276