| Literature DB >> 24508525 |
Mousumi Dutta1, Debosree Ghosh2, Arnab Kumar Ghosh2, Gargi Bose2, Aindrila Chattopadhyay3, Smita Rudra2, Monalisa Dey2, Arkita Bandyopadhyay2, Sanjib K Pattari4, Sanjaya Mallick5, Debasish Bandyopadhyay6.
Abstract
Arsenic is a well known global groundwater contaminant. Exposure of human body to arsenic causes various hazardous effects via oxidative stress. Nutrition is an important susceptible factor which can affect arsenic toxicity by several plausible mechanisms. Development of modern civilization led to alteration in the lifestyle as well as food habits of the people both in urban and rural areas which led to increased use of junk food containing high level of fat. The present study was aimed at investigating the effect of high fat diet on heart and liver tissues of rats when they were co-treated with arsenic. This study was established by elucidating heart weight to body weight ratio as well as analysis of the various functional markers, oxidative stress biomarkers and also the activity of the antioxidant enzymes. Histological analysis confirmed the biochemical investigations. From this study it can be concluded that high fat diet increased arsenic induced oxidative stress.Entities:
Keywords: Arsenic; Heart damage; High fat diet; Liver damage; Oxidative stress
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Year: 2014 PMID： 24508525 DOI： 10.1016/j.fct.2014.01.050
Source DB: PubMed Journal: Food Chem Toxicol ISSN： 0278-6915 Impact factor: 6.023