Sébastien Hulo1, Nathalie Chérot-Kornobis2, Mike Howsam3, Sébastien Crucq4, Virginie de Broucker5, Annie Sobaszek6, Jean-Louis Edme7. 1. Univ Lille Nord de France, F-59000 Lille, France; UDSL, EA 4483, F-59000 Lille, France; CHU Lille, F-59000 Lille, France. Electronic address: sebastien.hulo@univ-lille2.fr. 2. Univ Lille Nord de France, F-59000 Lille, France; UDSL, EA 4483, F-59000 Lille, France; CHU Lille, F-59000 Lille, France. Electronic address: nathalie.cherot@univ-lille2.fr. 3. Univ Lille Nord de France, F-59000 Lille, France; CUMA Lille, F-59006 Lille, France. Electronic address: michael.howsam@univ-lille2.fr. 4. ASTAV, F-59880 Valenciennes, France. Electronic address: sebastien.crucq@astav.fr. 5. Univ Lille Nord de France, F-59000 Lille, France; UDSL, EA 4483, F-59000 Lille, France; CHU Lille, F-59000 Lille, France. Electronic address: virginie.debroucker@chru-lille.fr. 6. Univ Lille Nord de France, F-59000 Lille, France; UDSL, EA 4483, F-59000 Lille, France; CHU Lille, F-59000 Lille, France. Electronic address: annie.sobaszek@univ-lille2.fr. 7. Univ Lille Nord de France, F-59000 Lille, France; UDSL, EA 4483, F-59000 Lille, France; CHU Lille, F-59000 Lille, France. Electronic address: jledme@univ-lille2.fr.
Abstract
OBJECTIVE: To evaluate manganese in exhaled breath condensate (Mn-EBC) as an indicator of exposure to fumes from metal inert gas welding process. METHODS: We collected EBC and urine from 17 welders and 16 unexposed control subjects after 5 days exposure. Concentrations of manganese (Mn), nickel (Ni), iron (Fe) and chromium (Cr) were measured in EBC and urine samples and correlated with cumulative exposure indices for the working week (CIW) and for the total welding years (WY), based on duration of welding activity and atmospheric metal measurements. RESULTS: Concentrations of Mn and Ni in EBC were significantly higher among welders than controls whereas this difference was not significant for Mn in urine. Levels of Mn and Ni in EBC were not correlated with their respective levels in urine. The linear regressions found significant positive coefficients between Mn-EBC, Ni-EBC, Ni-U and Cr-U concentrations and the cumulative exposure indices. Taking into account tobacco use, statistical analysis showed the same trends except for the relationship between Mn-U and CIW. CONCLUSION: This pilot study showed that Mn-EBC, as well as Ni-EBC, can serve as reliable indices of occupational exposure to welding fumes and provide complimentary toxicokinetic information to that provided by urine analyses.
OBJECTIVE: To evaluate manganese in exhaled breath condensate (Mn-EBC) as an indicator of exposure to fumes from metal inert gas welding process. METHODS: We collected EBC and urine from 17 welders and 16 unexposed control subjects after 5 days exposure. Concentrations of manganese (Mn), nickel (Ni), iron (Fe) and chromium (Cr) were measured in EBC and urine samples and correlated with cumulative exposure indices for the working week (CIW) and for the total welding years (WY), based on duration of welding activity and atmospheric metal measurements. RESULTS: Concentrations of Mn and Ni in EBC were significantly higher among welders than controls whereas this difference was not significant for Mn in urine. Levels of Mn and Ni in EBC were not correlated with their respective levels in urine. The linear regressions found significant positive coefficients between Mn-EBC, Ni-EBC, Ni-U and Cr-U concentrations and the cumulative exposure indices. Taking into account tobacco use, statistical analysis showed the same trends except for the relationship between Mn-U and CIW. CONCLUSION: This pilot study showed that Mn-EBC, as well as Ni-EBC, can serve as reliable indices of occupational exposure to welding fumes and provide complimentary toxicokinetic information to that provided by urine analyses.
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