Literature DB >> 24508262

MicroRNA mediates DNA methylation of target genes.

Wangxiong Hu1, Tingzhang Wang2, Jianhong Xu2, Hongzhi Li3.   

Abstract

Small RNAs represented by microRNA (miRNA) plays important roles in plant development and responds to biotic and abiotic stresses. Previous studies have placed special emphasis on gene-repression mediated by miRNA. In this work, the DNA methylation pattern of microRNA genes (MIRs) was interrogated. Full-length cDNA and EST were used to confirm the entity of pri-miRNA. In parallel, miRNA in 24 nucleotides (nt) was pooled to detect chromatin modification effect by using bisulfite sequencing data. 97 MIRs were supported by full-length cDNA and 30 more were hit by EST. Notably, methylation levels of conserved MIRs were significantly lower than the non-conserved at all contexts (CG, CHG, and CHH). Additionally, a substantial part of 24-nt miRNA was able to induce target site methylation, providing a broader perspective for researchers.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  DNA methylation; Gene ontology; MicroRNA; RNA-directed DNA methylation

Mesh：

Substances：

Year:  2014        PMID： 24508262     DOI： 10.1016/j.bbrc.2014.01.171

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

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  8 in total

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