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Literature DB >> 24507714

Back to bases: how a nucleotide biosynthetic enzyme controls p53 activation.

Abstract

In this issue, Reddy et al. (2014) reveal a new twist in the molecular mechanism leading to p53 activation upon cellular stress, illuminating an unexpected nuclear role for a nucleotide biosynthetic enzyme in regulation of a potent tumor suppressor.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 2014 PMID： 24507714 PMCID： PMC3966567 DOI： 10.1016/j.molcel.2014.01.025

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

10 in total

1. Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization.

Authors: Muyang Li; Delin Chen; Ariel Shiloh; Jianyuan Luo; Anatoly Y Nikolaev; Jun Qin; Wei Gu
Journal: Nature Date: 2002-03-31 Impact factor: 49.962

2. A dynamic role of HAUSP in the p53-Mdm2 pathway.

Authors: Muyang Li; Christopher L Brooks; Ning Kon; Wei Gu
Journal: Mol Cell Date: 2004-03-26 Impact factor: 17.970

3. Tumour suppression: disruption of HAUSP gene stabilizes p53.

Authors: Jordan M Cummins; Carlo Rago; Manu Kohli; Kenneth W Kinzler; Christoph Lengauer; Bert Vogelstein
Journal: Nature Date: 2004-04-01 Impact factor: 49.962

Review 4. Blinded by the Light: The Growing Complexity of p53.

Authors: Karen H Vousden; Carol Prives
Journal: Cell Date: 2009-05-01 Impact factor: 41.582

5. 5S ribosomal RNA is an essential component of a nascent ribosomal precursor complex that regulates the Hdm2-p53 checkpoint.

Authors: Giulio Donati; Suresh Peddigari; Carol A Mercer; George Thomas
Journal: Cell Rep Date: 2013-07-03 Impact factor: 9.423

1 in total

1. G2/M checkpoint plays a vital role at the early stage of HCC by analysis of key pathways and genes.

Authors: Li Yin; Cuifang Chang; Cunshuan Xu
Journal: Oncotarget Date: 2017-07-18

1 in total

Back to bases: how a nucleotide biosynthetic enzyme controls p53 activation.

1. Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization.

2. A dynamic role of HAUSP in the p53-Mdm2 pathway.

3. Tumour suppression: disruption of HAUSP gene stabilizes p53.

Review 4. Blinded by the Light: The Growing Complexity of p53.

5. 5S ribosomal RNA is an essential component of a nascent ribosomal precursor complex that regulates the Hdm2-p53 checkpoint.

6. GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7.

Review 7. Awakening guardian angels: drugging the p53 pathway.

8. HAUSP is required for p53 destabilization.

9. Enzymes of purine metabolism in cancer.

10. The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress.

1. G2/M checkpoint plays a vital role at the early stage of HCC by analysis of key pathways and genes.