Literature DB >> 24507620

Immunostimulant patches containing Escherichia coli LT enhance immune responses to DNA- and recombinant protein-based Alzheimer's disease vaccines.

Hayk Davtyan1, Anahit Ghochikyan1, Armine Hovakimyan1, Irina Petrushina2, Jianmei Yu3, David Flyer3, Peter Juul Madsen4, Lars Ostergaard Pedersen4, David H Cribbs5, Michael G Agadjanyan6.   

Abstract

Immunotherapeutic approaches to treating Alzheimer's disease (AD) using vaccination strategies must overcome the obstacle of achieving adequate responses to vaccination in the elderly. Here we demonstrate for the first time that application of the Escherichia coli heat-labile enterotoxin adjuvant-laden immunostimulatory patches (LT-IS) dramatically enhances the onset and magnitude of immune responses to DNA- and protein-based vaccines for Alzheimer's disease following intradermal immunization via gene gun and conventional needles, respectively. Our studies suggest that the immune activation mediated by LT-IS offers improved potency for generating AD-specific vaccination responses that should be investigated as an adjuvant in the clinical arena.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Alzheimer's disease; Epitope vaccine; Immune responses; Immunostimulatory patch

Mesh：

Substances：

Year:  2014        PMID： 24507620      PMCID： PMC3951952          DOI： 10.1016/j.jneuroim.2014.01.002

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  44 in total

1.  Delivery of a DNA vaccine for Alzheimer's disease by electroporation versus gene gun generates potent and similar immune responses.

Authors:  Hayk Davtyan; Anahit Ghochikyan; Nina Movsesyan; Barry Ellefsen; Irina Petrushina; David H Cribbs; Drew Hannaman; Claire F Evans; Michael G Agadjanyan
Journal:  Neurodegener Dis       Date:  2012-02-01       Impact factor: 2.977

2.  Prototype Alzheimer's disease epitope vaccine induced strong Th2-type anti-Abeta antibody response with Alum to Quil A adjuvant switch.

Authors:  Anahit Ghochikyan; Mikayel Mkrtichyan; Irina Petrushina; Nina Movsesyan; Adrine Karapetyan; David H Cribbs; Michael G Agadjanyan
Journal:  Vaccine       Date:  2005-12-05       Impact factor: 3.641

3.  Microspheres containing plasmid-encoded antigens elicit cytotoxic T-cell responses.

Authors:  M L Hedley; J Curley; R Urban
Journal:  Nat Med       Date:  1998-03       Impact factor: 53.440

4.  Poly(DL-lactide-co-glycolide)-encapsulated plasmid DNA elicits systemic and mucosal antibody responses to encoded protein after oral administration.

Authors:  D H Jones; S Corris; S McDonald; J C Clegg; G H Farrar
Journal:  Vaccine       Date:  1997-06       Impact factor: 3.641

5.  Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid.

Authors:  David H Cribbs; Anahit Ghochikyan; Vitaly Vasilevko; Mike Tran; Irina Petrushina; Nadya Sadzikava; Davit Babikyan; Patrick Kesslak; Thomas Kieber-Emmons; Carl W Cotman; Michael G Agadjanyan
Journal:  Int Immunol       Date:  2003-04       Impact factor: 4.823

Review 6.  Induction of immune responses by DNA vaccines in large animals.

Authors:  L A Babiuk; R Pontarollo; S Babiuk; B Loehr; S van Drunen Littel-van den Hurk
Journal:  Vaccine       Date:  2003-01-30       Impact factor: 3.641

Review 7.  DNA vaccines: ready for prime time?

Authors:  Michele A Kutzler; David B Weiner
Journal:  Nat Rev Genet       Date:  2008-10       Impact factor: 53.242

8.  Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice.

Authors:  Irina Petrushina; Anahit Ghochikyan; Mikayel Mktrichyan; Gregory Mamikonyan; Nina Movsesyan; Hayk Davtyan; Archita Patel; Elizabeth Head; David H Cribbs; Michael G Agadjanyan
Journal:  J Neurosci       Date:  2007-11-14       Impact factor: 6.167

9.  Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease.

Authors:  N C Fox; R S Black; S Gilman; M N Rossor; S G Griffith; L Jenkins; M Koller
Journal:  Neurology       Date:  2005-05-10       Impact factor: 9.910

10.  Safety and immunogenicity of a prototype enterotoxigenic Escherichia coli vaccine administered transcutaneously.

Authors:  Fernando Güereña-Burgueño; Eric R Hall; David N Taylor; Frederick J Cassels; Daniel A Scott; Marcia K Wolf; Zachary J Roberts; Galina V Nesterova; Carl R Alving; Gregory M Glenn
Journal:  Infect Immun       Date:  2002-04       Impact factor: 3.441
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  3 in total

1.  Comparison of Efficacy of Preventive and Therapeutic Vaccines Targeting the N Terminus of β-Amyloid in an Animal Model of Alzheimer's Disease.

Authors:  Irina Petrushina; Hayk Davtyan; Armine Hovakimyan; Arpine Davtyan; Giselle F Passos; David H Cribbs; Anahit Ghochikyan; Michael G Agadjanyan
Journal:  Mol Ther       Date:  2017-01-04       Impact factor: 11.454

2.  Alzheimer's disease: is a vaccine possible?

Authors:  R P S Alves; M J Yang; M T Batista; L C S Ferreira
Journal:  Braz J Med Biol Res       Date:  2014-06-03       Impact factor: 2.590

3.  Efficacy and Safety of the Immunization with DNA for Alzheimer's Disease in Animal Models: A Systematic Review from Literature.

Authors:  Yandara Akamine Martins; Cristiane Jumko Tsuchida; Patrícia Antoniassi; Izabel Galhardo Demarchi
Journal:  J Alzheimers Dis Rep       Date:  2017-12-02
  3 in total

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