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Literature DB >> 24506877

Turning reactive glia into functional neurons in the brain.

Jianfeng Lu¹, Robert A Bradley¹, Su-Chun Zhang².

Abstract

Following brain injury, reactive glial cells can create scars that inhibit neural repair responses. In this issue of Cell Stem Cell, Guo et al. report that overexpression of NeuroD1 in vivo can directly reprogram reactive glial cells into glutamatergic and GABAergic neurons that integrate into the host's neural circuitry.

Entities: CellLine Disease Gene Species

Mesh：

Year: 2014 PMID： 24506877 PMCID： PMC4018986 DOI： 10.1016/j.stem.2014.01.010

Source DB: PubMed Journal: Cell Stem Cell ISSN： 1875-9777 Impact factor: 24.633

9 in total

Review 1. Induced neuronal cells: how to make and define a neuron.

Authors: Nan Yang; Yi Han Ng; Zhiping P Pang; Thomas C Südhof; Marius Wernig
Journal: Cell Stem Cell Date: 2011-12-02 Impact factor: 24.633

2. Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor.

Authors: Karen L Ring; Leslie M Tong; Maureen E Balestra; Robyn Javier; Yaisa Andrews-Zwilling; Gang Li; David Walker; William R Zhang; Anatol C Kreitzer; Yadong Huang
Journal: Cell Stem Cell Date: 2012-06-07 Impact factor: 24.633

3. In vivo reprogramming of astrocytes to neuroblasts in the adult brain.

Authors: Wenze Niu; Tong Zang; Yuhua Zou; Sanhua Fang; Derek K Smith; Robert Bachoo; Chun-Li Zhang
Journal: Nat Cell Biol Date: 2013-09-22 Impact factor: 28.824

4. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

Authors: Kazutoshi Takahashi; Shinya Yamanaka
Journal: Cell Date: 2006-08-10 Impact factor: 41.582

5. In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model.

Authors: Ziyuan Guo; Lei Zhang; Zheng Wu; Yuchen Chen; Fan Wang; Gong Chen
Journal: Cell Stem Cell Date: 2013-12-19 Impact factor: 24.633

6. Functional properties of neurons derived from in vitro reprogrammed postnatal astroglia.

Authors: Benedikt Berninger; Marcos R Costa; Ursula Koch; Timm Schroeder; Bernd Sutor; Benedikt Grothe; Magdalena Götz
Journal: J Neurosci Date: 2007-08-08 Impact factor: 6.167

7. Generation of integration-free and region-specific neural progenitors from primate fibroblasts.

Authors: Jianfeng Lu; Huisheng Liu; Cindy Tzu-Ling Huang; Hong Chen; Zhongwei Du; Yan Liu; Mohammad Amin Sherafat; Su-Chun Zhang
Journal: Cell Rep Date: 2013-05-02 Impact factor: 9.423

8. Induction of human neuronal cells by defined transcription factors.

Authors: Zhiping P Pang; Nan Yang; Thomas Vierbuchen; Austin Ostermeier; Daniel R Fuentes; Troy Q Yang; Ami Citri; Vittorio Sebastiano; Samuele Marro; Thomas C Südhof; Marius Wernig
Journal: Nature Date: 2011-05-26 Impact factor: 49.962

9. Direct conversion of fibroblasts to functional neurons by defined factors.

Authors: Thomas Vierbuchen; Austin Ostermeier; Zhiping P Pang; Yuko Kokubu; Thomas C Südhof; Marius Wernig
Journal: Nature Date: 2010-01-27 Impact factor: 49.962

9 in total

5 in total

Review 5. Current understanding of neuroinflammation after traumatic brain injury and cell-based therapeutic opportunities.

Authors: Ye Xiong; Asim Mahmood; Michael Chopp
Journal: Chin J Traumatol Date: 2018-04-24