Literature DB >> 24506876

Getting off the ground state: X chromosome inactivation knocks down barriers to differentiation.

Robert Morey1, Louise C Laurent2.   

Abstract

Female mouse embryonic stem cells (mESCs) contain two active X chromosomes, with one undergoing random inactivation upon differentiation. Schulz et al. (2014) now demonstrate that the presence of two active X chromosomes in mESCs prevents exit from pluripotency by blocking MAPK signaling, ensuring synchronization between X chromosome dosage compensation and development.
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID： 24506876      PMCID： PMC3984128          DOI： 10.1016/j.stem.2014.01.012

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  10 in total

1.  Molecular coupling of Xist regulation and pluripotency.

Authors:  Pablo Navarro; Ian Chambers; Violetta Karwacki-Neisius; Corinne Chureau; Céline Morey; Claire Rougeulle; Philip Avner
Journal:  Science       Date:  2008-09-19       Impact factor: 47.728

2.  Derivation of novel human ground state naive pluripotent stem cells.

Authors:  Ohad Gafni; Leehee Weinberger; Abed AlFatah Mansour; Yair S Manor; Elad Chomsky; Dalit Ben-Yosef; Yael Kalma; Sergey Viukov; Itay Maza; Asaf Zviran; Yoach Rais; Zohar Shipony; Zohar Mukamel; Vladislav Krupalnik; Mirie Zerbib; Shay Geula; Inbal Caspi; Dan Schneir; Tamar Shwartz; Shlomit Gilad; Daniela Amann-Zalcenstein; Sima Benjamin; Ido Amit; Amos Tanay; Rada Massarwa; Noa Novershtern; Jacob H Hanna
Journal:  Nature       Date:  2013-10-30       Impact factor: 49.962

Review 3.  Regulation of X-chromosome inactivation by the X-inactivation centre.

Authors:  Sandrine Augui; Elphège P Nora; Edith Heard
Journal:  Nat Rev Genet       Date:  2011-06       Impact factor: 53.242

4.  The two active X chromosomes in female ESCs block exit from the pluripotent state by modulating the ESC signaling network.

Authors:  Edda G Schulz; Johannes Meisig; Tomonori Nakamura; Ikuhiro Okamoto; Anja Sieber; Christel Picard; Maud Borensztein; Mitinori Saitou; Nils Blüthgen; Edith Heard
Journal:  Cell Stem Cell       Date:  2014-02-06       Impact factor: 24.633

Review 5.  Blastocysts prepare for the race to be male.

Authors:  U Mittwoch
Journal:  Hum Reprod       Date:  1993-10       Impact factor: 6.918

Review 6.  X chromosome inactivation and epigenetic responses to cellular reprogramming.

Authors:  Derek Lessing; Montserrat C Anguera; Jeannie T Lee
Journal:  Annu Rev Genomics Hum Genet       Date:  2013-05-06       Impact factor: 8.929

7.  Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives.

Authors:  Kristopher L Nazor; Gulsah Altun; Candace Lynch; Ha Tran; Julie V Harness; Ileana Slavin; Ibon Garitaonandia; Franz-Josef Müller; Yu-Chieh Wang; Francesca S Boscolo; Eyitayo Fakunle; Biljana Dumevska; Sunray Lee; Hyun Sook Park; Tsaiwei Olee; Darryl D D'Lima; Ruslan Semechkin; Mana M Parast; Vasiliy Galat; Andrew L Laslett; Uli Schmidt; Hans S Keirstead; Jeanne F Loring; Louise C Laurent
Journal:  Cell Stem Cell       Date:  2012-05-04       Impact factor: 24.633

Review 8.  Epigenetic alterations in human pluripotent stem cells: a tale of two cultures.

Authors:  Anton Wutz
Journal:  Cell Stem Cell       Date:  2012-07-06       Impact factor: 24.633

9.  Detrimental effects of two active X chromosomes on early mouse development.

Authors:  N Takagi; K Abe
Journal:  Development       Date:  1990-05       Impact factor: 6.868

Review 10.  Evolutionary diversity and developmental regulation of X-chromosome inactivation.

Authors:  Martin Escamilla-Del-Arenal; Simao Teixeira da Rocha; Edith Heard
Journal:  Hum Genet       Date:  2011-06-18       Impact factor: 4.132
  10 in total
  2 in total

1.  Derivation and maintenance of mouse haploid embryonic stem cells.

Authors:  Ulrich Elling; Michael Woods; Josep V Forment; Beiyuan Fu; Fengtang Yang; Bee Ling Ng; Jose R Vicente; David J Adams; Brendan Doe; Stephen P Jackson; Josef M Penninger; Gabriel Balmus
Journal:  Nat Protoc       Date:  2019-06-03       Impact factor: 13.491

Review 2.  Mechanisms of x chromosome dosage compensation.

Authors:  Sevinç Ercan
Journal:  J Genomics       Date:  2015-01-01
  2 in total

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