| Literature DB >> 24506863 |
Tomas A Prolla1, John M Denu2.
Abstract
Age-related mitochondrial dysfunction is thought to contribute to mammalian aging, particularly in postmitotic tissues that rely heavily on oxidative phosphorylation. A new study (Gomes et al., 2013) shows that reduced levels of nicotinamide adenine dinucleotide (NAD(+)) contribute to the mitochondrial decay associated with skeletal muscle aging and that sirtuin 1 (SIRT1) modulates this process.Entities:
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Year: 2014 PMID： 24506863 DOI： 10.1016/j.cmet.2014.01.005
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287