Literature DB >> 2450583

Bupivacaine is an effective potassium channel blocker in heart.

K R Courtney1, J J Kendig.   

Abstract

The local anesthetic agent bupivacaine increases action potential duration in isolated frog atrial myocytes, and blocks two potassium conductances, IK and IK1. The effective concentrations, particularly for IK, are similar to those which depress the sodium conductance. Potassium channel block may thus contribute to bupivacaine's reported cardiotoxicity.

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Year:  1988        PMID： 2450583     DOI： 10.1016/0005-2736(88)90058-2

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  9 in total

1.  Mechanism underlying bupivacaine inhibition of G protein-gated inwardly rectifying K+ channels.

Authors:  W Zhou; C Arrabit; S Choe; P A Slesinger
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-15       Impact factor: 11.205

Review 2.  [Toxicology of local anesthetics. Clinical, therapeutic and pathological mechanisms].

Authors:  W Zink; B M Graf
Journal:  Anaesthesist       Date:  2003-12       Impact factor: 1.041

3.  Potassium channel agonists modify the local anaesthetic activity of bupivacaine in mice.

Authors:  M Gantenbein; L Attolini; B Bruguerolle
Journal:  Can J Anaesth       Date:  1996-08       Impact factor: 5.063

4.  Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers.

Authors:  C Valenzuela; E Delpón; M M Tamkun; J Tamargo; D J Snyders
Journal:  Biophys J       Date:  1995-08       Impact factor: 4.033

5.  Bupivacaine inhibits a small conductance calcium-activated potassium type 2 channel in human embryonic kidney 293 cells.

Authors:  Hongfei Chen; Zhousheng Jin; Fangfang Xia; Zhijian Fu
Journal:  BMC Pharmacol Toxicol       Date:  2021-03-12       Impact factor: 2.483

6.  Epinephrine reversed high-concentration bupivacaine-induced inhibition of calcium channels and transient outward potassium current channels, but not on sodium channel in ventricular myocytes of rats.

Authors:  Fuli Liu; Bingjing Wu; Yongjun Du; Yiquan Wu; Hongfei Chen; Fangfang Xia; Zhousheng Jin; Xuzhong Xu
Journal:  BMC Anesthesiol       Date:  2015-04-30       Impact factor: 2.217

7.  Hyaluronan Does Not Affect Bupivacaine's Inhibitory Action on Voltage-Gated Potassium Channel Activities in Bovine Articular Chondrocytes.

Authors:  William Hester; Jinnan Yang; Guo-Yong Wang; Sen Liu; Michael J O'Brien; Felix H Savoie; Zongbing You
Journal:  Adv Orthop       Date:  2012-04-22

8.  Methadone block of K+ current in squid giant fiber lobe neurons.

Authors:  F T Horrigan; W F Gilly
Journal:  J Gen Physiol       Date:  1996-02       Impact factor: 4.086

9.  Levosimendan is superior to epinephrine on coronary flow for lipid-base resuscitation of bupivacaine-induced asystole in the isolated rat heart.

Authors:  Hongfei Chen; Fangfang Xia; Zhousheng Jin; Kejian Shi; Yun Xia; Le Liu; Thomas J Papadimos; Xuzhong Xu; Limei Chen
Journal:  BMC Anesthesiol       Date:  2018-11-20       Impact factor: 2.217
  9 in total

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