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1. Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4.

Authors: Fabrizio Semeraro; Concetta T Ammollo; James H Morrissey; George L Dale; Paul Friese; Naomi L Esmon; Charles T Esmon
Journal: Blood Date: 2011-06-14 Impact factor: 22.113

2. Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation.

Authors: C T Ammollo; F Semeraro; J Xu; N L Esmon; C T Esmon
Journal: J Thromb Haemost Date: 2011-09 Impact factor: 5.824

Review 3. Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway.

Authors: E A M Bouwens; F Stavenuiter; L O Mosnier
Journal: J Thromb Haemost Date: 2013-06 Impact factor: 5.824

4. Activated factor V is a cofactor for the activation of factor XI by thrombin in plasma.

Authors: Coen Maas; Joost C M Meijers; J Arnoud Marquart; Kamran Bakhtiari; Cees Weeterings; Philip G de Groot; Rolf T Urbanus
Journal: Proc Natl Acad Sci U S A Date: 2010-05-03 Impact factor: 11.205

5. Histones induce rapid and profound thrombocytopenia in mice.

Authors: Tobias A Fuchs; Ashish A Bhandari; Denisa D Wagner
Journal: Blood Date: 2011-06-23 Impact factor: 22.113

6. Polyphosphate amplifies proinflammatory responses of nuclear proteins through interaction with receptor for advanced glycation end products and P2Y1 purinergic receptor.

Authors: Peyman Dinarvand; Seyed Mahdi Hassanian; Shabir H Qureshi; Chandrashekhara Manithody; Joel C Eissenberg; Likui Yang; Alireza R Rezaie
Journal: Blood Date: 2013-11-19 Impact factor: 22.113

PolyP and APC fight a RAGEing battle.

1. Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4.

2. Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation.

Review 3. Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway.

4. Activated factor V is a cofactor for the activation of factor XI by thrombin in plasma.

5. Histones induce rapid and profound thrombocytopenia in mice.

6. Polyphosphate amplifies proinflammatory responses of nuclear proteins through interaction with receptor for advanced glycation end products and P2Y1 purinergic receptor.

7. Activated protein C inhibits high mobility group box 1 signaling in endothelial cells.

Review 8. Polyphosphate: an ancient molecule that links platelets, coagulation, and inflammation.

9. Inhibition of polyphosphate as a novel strategy for preventing thrombosis and inflammation.

10. Extracellular histones are major mediators of death in sepsis.