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Literature DB >> 24504450

Overexpressed RACK1 is positively correlated with malignant degree of human colorectal carcinoma.

Shaoju Jin¹, Yishuang Mu, Xiaodong Wang, Zhenru Liu, Lihong Wan, Yao Xiong, Yuanyuan Zhang, Liming Zhou, Li Li.

Abstract

RACK1 is a crucial scaffold and anchoring protein, which plays a vital role in multiple signaling pathways of tumorigenesis. The aim of the present study was to identify the correlation between expressions of RACK1 and malignant degrees in colorectal carcinoma (CRC) patients. All together 157 CRC patients were enrolled, and their clinical data were analyzed. Expressions of RACK1 in CRC and pericarcinous tissues in these patients were determined by RT-PCR, Western-blot, and immunohistochemistry, respectively. The correlation between RACK1 expressions and histological grades, as well as lymph node metastasis was evaluated. Results showed that the expressions of RACK1 were positively correlated with differentiation level and lymph node metastasis in CRC patients.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2014 PMID： 24504450 DOI： 10.1007/s11033-014-3201-y

Source DB: PubMed Journal: Mol Biol Rep ISSN： 0301-4851 Impact factor: 2.316

25 in total

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Authors: Arnaud Besson; Tammy L Wilson; V Wee Yong
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4. Gel-Based Proteomics of Clinical Samples Identifies Potential Serological Biomarkers for Early Detection of Colorectal Cancer.

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