Literature DB >> 2450379

Structure and function of SV40 large-T antigen.

S E Mole1, J V Gannon, M J Ford, D P Lane.   

Abstract

The small eukaryotic DNA tumour virus, SV40, has long provided a very useful model for the study of eukaryotic DNA replication and cellular transformation. The viral gene product, large-tumour (large-T) antigen, is essential for the initiation of viral DNA replication and the initiation and maintenance of SV40-virus-mediated cellular transformation. The large-T antigen is a complex multifunctional protein, and to delineate its activity more precisely in viral DNA replication and cellular transformation, small functional domains of the protein have been expressed in Escherichia coli and analysed by using a very extensive library of anti-T monoclonal antibodies.

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Year:  1987        PMID： 2450379     DOI： 10.1098/rstb.1987.0072

Source DB:  PubMed          Journal:  Philos Trans R Soc Lond B Biol Sci        ISSN： 0962-8436            Impact factor:   6.237


  32 in total

Review 1.  Simian virus 40 large T antigen: the puzzle, the pieces, and the emerging picture.

Authors:  E Fanning
Journal:  J Virol       Date:  1992-03       Impact factor: 5.103

Review 2.  Recognition mechanisms in the synthesis of animal virus DNA.

Authors:  R T Hay; W C Russell
Journal:  Biochem J       Date:  1989-02-15       Impact factor: 3.857

3.  Large T-antigen double hexamers imaged at the simian virus 40 origin of replication.

Authors:  M Valle; C Gruss; L Halmer; J M Carazo; L E Donate
Journal:  Mol Cell Biol       Date:  2000-01       Impact factor: 4.272

4.  p300 family members associate with the carboxyl terminus of simian virus 40 large tumor antigen.

Authors:  N L Lill; M J Tevethia; R Eckner; D M Livingston; N Modjtahedi
Journal:  J Virol       Date:  1997-01       Impact factor: 5.103

5.  Properties of the DNA-binding domain of the simian virus 40 large T antigen.

Authors:  D McVey; M Strauss; Y Gluzman
Journal:  Mol Cell Biol       Date:  1989-12       Impact factor: 4.272

6.  The large tumor antigen of simian virus 40 encodes at least two distinct transforming functions.

Authors:  A Srinivasan; K W Peden; J M Pipas
Journal:  J Virol       Date:  1989-12       Impact factor: 5.103

Review 7.  Viral proteins containing the purine NTP-binding sequence pattern.

Authors:  A E Gorbalenya; E V Koonin
Journal:  Nucleic Acids Res       Date:  1989-11-11       Impact factor: 16.971

8.  Activation of endogenous retroviral transcription in SV40-transformed mouse cells.

Authors:  P M Timmons; P M Brickell; D S Latchman; P W Rigby
Journal:  Nucleic Acids Res       Date:  1991-12       Impact factor: 16.971

9.  Association of insulin receptor substrate 1 with simian virus 40 large T antigen.

Authors:  Z L Fei; C D'Ambrosio; S Li; E Surmacz; R Baserga
Journal:  Mol Cell Biol       Date:  1995-08       Impact factor: 4.272

10.  Coevolution of persistently infecting small DNA viruses and their hosts linked to host-interactive regulatory domains.

Authors:  F F Shadan; L P Villarreal
Journal:  Proc Natl Acad Sci U S A       Date:  1993-05-01       Impact factor: 11.205
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