PURPOSE: To determine the association of hydroxymethylglutarylcoenzyme A (HMG Co-A) reductase inhibitor (statin) use with the prevalence of age-related macular degeneration (AMD). METHODS: This cross-sectional study included 5604 participants in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2008, ≥ 40 years of age, who were ascertained with regard to the diagnosis of AMD, the use of statins, and comorbidities and health-related behaviors such as smoking. RESULTS: The mean age of participants denying or confirming a history of AMD was 68 (SEM 0.90) and 55 (SEM 0.36) years, respectively. Individuals 68 years of age or older who were classified as long-term users of statins had statistically significant less self-reported AMD (odds ratio (OR) 0.64, 95% confidence interval (CI) 0.49-0.84; P=0.002), after adjusting for potential confounding variables. No significant association was found between the prevalence of AMD and statin consumption among subjects between 40 and 67 years of age (OR 1.61, 95% CI 0.85-3.03; P=0.137). CONCLUSIONS: Our results suggest a possible beneficial effect of statin intake for the prevention of AMD in individuals 68 years of age or older.
PURPOSE: To determine the association of hydroxymethylglutarylcoenzyme A (HMG Co-A) reductase inhibitor (statin) use with the prevalence of age-related macular degeneration (AMD). METHODS: This cross-sectional study included 5604 participants in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2008, ≥ 40 years of age, who were ascertained with regard to the diagnosis of AMD, the use of statins, and comorbidities and health-related behaviors such as smoking. RESULTS: The mean age of participants denying or confirming a history of AMD was 68 (SEM 0.90) and 55 (SEM 0.36) years, respectively. Individuals 68 years of age or older who were classified as long-term users of statins had statistically significant less self-reported AMD (odds ratio (OR) 0.64, 95% confidence interval (CI) 0.49-0.84; P=0.002), after adjusting for potential confounding variables. No significant association was found between the prevalence of AMD and statin consumption among subjects between 40 and 67 years of age (OR 1.61, 95% CI 0.85-3.03; P=0.137). CONCLUSIONS: Our results suggest a possible beneficial effect of statin intake for the prevention of AMD in individuals 68 years of age or older.
Authors: Amar U Kishan; Bobeck S Modjtahedi; Elisabeth N Martins; Sara P Modjtahedi; Lawrence S Morse Journal: Surv Ophthalmol Date: 2011-03-25 Impact factor: 6.048
Authors: Shaza N Al-Holou; William R Tucker; Elvira Agrón; Traci E Clemons; Catherine Cukras; Frederick L Ferris; Emily Y Chew Journal: Ophthalmology Date: 2015-10-04 Impact factor: 12.079
Authors: Gopalan Gnanaguru; Ashley Mackey; Eun Young Choi; Anthoula Arta; Franco Aparecido Rossato; Thomas W Gero; Andrew J Urquhart; David A Scott; Patricia A D'Amore; Yin Shan E Ng Journal: Free Radic Biol Med Date: 2021-11-27 Impact factor: 7.376