Literature DB >> 24503471

Convergence of advances in genomics, team science, and repositories as drivers of progress in psychiatric genomics.

Thomas Lehner1, Geetha Senthil2, Anjené M Addington2.   

Abstract

After many years of unfilled promise, psychiatric genetics has seen an unprecedented number of successes in recent years. We hypothesize that the field has reached an inflection point through a confluence of four key developments: advances in genomics; the orientation of the scientific community around large collaborative team science projects; the development of sample and data repositories; and a policy framework for sharing and accessing these resources. We discuss these domains and their effect on scientific progress and provide a perspective on why we think this is only the beginning of a new era in scientific discovery. Published by Elsevier Inc.

Entities:  

Keywords:  Biosamples; Data Sharing; NIMH Repository and Genomics Resource; Psychiatric Genomics; Team Science; dbGaP

Mesh:

Year:  2014        PMID: 24503471     DOI: 10.1016/j.biopsych.2014.01.003

Source DB:  PubMed          Journal:  Biol Psychiatry        ISSN: 0006-3223            Impact factor:   13.382


  5 in total

Review 1.  The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.

Authors:  A Jeremy Willsey; Montana T Morris; Sheng Wang; Helen R Willsey; Nawei Sun; Nia Teerikorpi; Tierney B Baum; Gerard Cagney; Kevin J Bender; Tejal A Desai; Deepak Srivastava; Graeme W Davis; Jennifer Doudna; Edward Chang; Vikaas Sohal; Daniel H Lowenstein; Hao Li; David Agard; Michael J Keiser; Brian Shoichet; Mark von Zastrow; Lennart Mucke; Steven Finkbeiner; Li Gan; Nenad Sestan; Michael E Ward; Ruth Huttenhain; Tomasz J Nowakowski; Hugo J Bellen; Loren M Frank; Mustafa K Khokha; Richard P Lifton; Martin Kampmann; Trey Ideker; Matthew W State; Nevan J Krogan
Journal:  Cell       Date:  2018-07-26       Impact factor: 41.582

2.  Genomic resources for the study of neuropsychiatric disorders.

Authors:  G Senthil; T Dutka; L Bingaman; T Lehner
Journal:  Mol Psychiatry       Date:  2017-03-21       Impact factor: 15.992

3.  The expanding scope of psychiatric epidemiology in the 21st century.

Authors:  Katherine M Keyes; Ezra Susser
Journal:  Soc Psychiatry Psychiatr Epidemiol       Date:  2014-08-06       Impact factor: 4.328

4.  Global mental health and neuroethics.

Authors:  Dan J Stein; James Giordano
Journal:  BMC Med       Date:  2015-03-04       Impact factor: 8.775

Review 5.  The impact of psychopharmacology on contemporary clinical psychiatry.

Authors:  Gustavo H Vázquez
Journal:  Can J Psychiatry       Date:  2014-08       Impact factor: 4.356

  5 in total

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