| Literature DB >> 24502538 |
Liu Hong1, Yu Han, Hongwei Zhang, Qingchuan Zhao, Kaichun Wu, Daiming Fan.
Abstract
Hepatocellular cancer is a hypervascular cancer characterized by rapid progression as well as resistance to chemotherapy. Drug resistance arises from the alteration of many molecules, including oncogenes, tumor suppressor genes and miRNAs. This review evaluates the advances of drug resistance-related miRNAs in hepatocellular cancer, and analyzes the value of them as prognostic biomarkers and therapeutic targets. This review also discusses the limitations of miRNA-based therapy, and envisages future developments toward the clinical applications of drug resistance-related miRNAs.Entities:
Mesh:
Substances:
Year: 2014 PMID: 24502538 DOI: 10.1586/17474124.2014.881713
Source DB: PubMed Journal: Expert Rev Gastroenterol Hepatol ISSN: 1747-4124 Impact factor: 3.869