Literature DB >> 24502521

Gageotetrins A-C, noncytotoxic antimicrobial linear lipopeptides from a marine bacterium Bacillus subtilis.

Fakir Shahidullah Tareq1, Min Ah Lee, Hyi-Seung Lee, Yeon-Ju Lee, Jong Seok Lee, Choudhury M Hasan, Md Tofazzal Islam, Hee Jae Shin.   

Abstract

Gageotetrins A-C (1-3), a unique class of linear lipopeptides, consisting of di- and tetrapeptides and a new fatty acid were isolated from a Marine Bacillus subtilis. The structures of 1-3 were assigned by spectroscopic data and their absolute stereochemistries were ascertained by chemical derivatization. Compounds 1-3 displayed good antimicrobial activities with MIC values of 0.01-0.06 μM. However, these compounds failed to register any cytotoxicity (GI50 > 30 μg/ml) against human cancer cell lines.

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Year:  2014        PMID： 24502521     DOI： 10.1021/ol403657r

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  19 in total

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8.  Benzotriazole-Mediated Synthesis and Antibacterial Activity of Novel N-Acylcephalexins.

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Review 9.  Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials.

Authors:  Alka Choudhary; Lynn M Naughton; Itxaso Montánchez; Alan D W Dobson; Dilip K Rai
Journal:  Mar Drugs       Date:  2017-08-28       Impact factor: 5.118

10.  Inhibitory Effects of Linear Lipopeptides From a Marine Bacillus subtilis on the Wheat Blast Fungus Magnaporthe oryzae Triticum.

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Journal:  Front Microbiol       Date:  2020-04-30       Impact factor: 5.640
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